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A selective BODIPY-based fluorescent sensor for the detection of Cu2+ ions in biological and environmental samples
被引:0
作者:
Eldem, Asli
[1
]
Kibris, Erman
[1
]
Ucuncu, Muhammed
[1
]
机构:
[1] Izmir Inst Technol, Fac Sci, Dept Chem, Izmir, Turkiye
关键词:
BODIPY;
Cu2+ sensing;
Cell imaging;
Real water samples;
Soil samples;
CHEMOSENSOR;
D O I:
10.1016/j.saa.2025.125909
中图分类号:
O433 [光谱学];
学科分类号:
0703 ;
070302 ;
摘要:
In this study, we present the design, synthesis, and characterization of a 'turn-on' fluorescent probe, BOD-HDZ, for the selective detection of Cu2+ ions in semi-aqueous solutions, environmental samples (water and soil), and MCF-7 cancer cells. BOD-HDZ was synthesized by functionalizing meso-formyl-BODIPY (BOD-ALD) with a 2-hydrazinopyridine, resulting in fluorescence quenching via a photoinduced electron transfer (PET) mechanism. The 1:1 coordination between Cu2+ and the probe was confirmed through Job's plot analysis and 1H NMR spectroscopy, leading to a 210-fold fluorescence enhancement at 515 nm. BOD-HDZ demonstrated exceptional sensing properties, including a rapid response time (<1 min), a broad operational pH range (2-12), and high sensitivity with a detection limit of 141 nM.
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页数:7
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