A selective BODIPY-based fluorescent sensor for the detection of Cu2+ ions in biological and environmental samples

被引：0
作者：
Eldem, Asli [1 ]
Kibris, Erman [1 ]
Ucuncu, Muhammed [1 ]
机构：
[1] Izmir Inst Technol, Fac Sci, Dept Chem, Izmir, Turkiye
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2025年 / 333卷
关键词：
BODIPY; Cu2+ sensing; Cell imaging; Real water samples; Soil samples; CHEMOSENSOR;
D O I：
10.1016/j.saa.2025.125909
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
In this study, we present the design, synthesis, and characterization of a 'turn-on' fluorescent probe, BOD-HDZ, for the selective detection of Cu2+ ions in semi-aqueous solutions, environmental samples (water and soil), and MCF-7 cancer cells. BOD-HDZ was synthesized by functionalizing meso-formyl-BODIPY (BOD-ALD) with a 2-hydrazinopyridine, resulting in fluorescence quenching via a photoinduced electron transfer (PET) mechanism. The 1:1 coordination between Cu2+ and the probe was confirmed through Job's plot analysis and 1H NMR spectroscopy, leading to a 210-fold fluorescence enhancement at 515 nm. BOD-HDZ demonstrated exceptional sensing properties, including a rapid response time (<1 min), a broad operational pH range (2-12), and high sensitivity with a detection limit of 141 nM.
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页数：7
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