Structural determination of two undescribed triterpenoids from Punica granatum L. peels

被引：0
作者：
Iguchi, Tomoki [1 ]
Shibata, Norika [1 ]
Ito, Hiyoka [1 ]
Shimazaki, Tamami [1 ]
Mimaki, Yoshihiro [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Dept Med Pharmacognosy, Hachioji, Tokyo 1920392, Japan
来源：
PHYTOCHEMISTRY LETTERS | 2025年 / 66卷
关键词：
Punica granatum; Lythraceae; Triterpenoid; Cytotoxicity; SBC-3; cell; ALPHA-GLUCOSIDASE; INHIBITORS; FLOWERS; ACIDS;
D O I：
10.1016/j.phytol.2025.02.005
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Seven triterpenoids (1-7) comprising four oleanane-type (1-4), two ursane-type (5 and 6), and one lupane-type (7), were isolated from Punica granatum L. peels. The structures of two undescribed compounds (1 and 2) were elucidated primarily by two-dimensional NMR spectroscopic analysis. This is the first reported isolation of 3, 6, and 7 from P. granatum. The cytotoxicity of 1-7 was evaluated in SBC-3 human small-cell lung cancer cells using a modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2-tetrazolium bromide assay. Compounds 3-7 exhibited moderate cytotoxicity against SBC-3 cells, with IC50 values ranging from 52 to 61 mu M.
引用
收藏
页码：54 / 59
页数：6
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