The Road More or Less Traveled- Examining the Role of Consolidative Allogeneic Hematopoietic Stem Cell Transplantation After Chimeric Antigen Receptor T Cell Therapy in B-cell ALL

被引：2

作者：

Choe, Michelle ^{[1
,2
]}

Summers, Corinne ^{[2
,3
]}

机构：

[1] Fred Hutch Canc Ctr, Clin Res Div, Seattle, WA USA

[2] Univ Washington, Dept Pediat, Seattle, WA USA

[3] Seattle Childrens Res Inst, Seattle Childrens Therapeut, 1920 Terry Ave, Seattle, WA 98101 USA

来源：

SEMINARS IN HEMATOLOGY | 2024年 / 61卷 / 05期

关键词：

Acute lymphoblastic leukemia; CD19; Chimeric antigen receptor T cells; Allogeneic hematopoietic stem cell; transplant; Consolidation; Relapse-free survival; MINIMAL RESIDUAL DISEASE; YOUNG-ADULTS; CHILDREN; LEUKEMIA; TISAGENLECLEUCEL; REMISSIONS;

D O I：

10.1053/j.seminhematol.2024.08.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment with CD19-targeted chimeric antigen receptor T cell therapy (CD19-CART) has improved salvage rates in children and adults with relapsed and/or refractory B-cell acute lymphoblastic leukemia (ALL). However, not all patients treated with CD19-CAR T cells achieve long-term remission. The role of allogeneic hematopoietic stem cell transplantation as consolidative therapy remains undefined. We aim to review the current literature published to date regarding prognostic markers indicating durable ALL response to CD19-CART and risk factors for relapse after CD19-CART to identify patient cohorts who may benefit from consolidative hematopoietic stem cell transplantation. (c) 2024 Published by Elsevier Inc.

引用

页码：314 / 320

页数：7

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