Compliant immune response of silk-based biomaterials broadens application in wound treatment

被引：1
作者：
Tian, Zhiqiang [1 ]
Chen, Hong [2 ]
Zhao, Ping [1 ]
机构：
[1] Southwest Univ, Biol Sci Res Ctr, Integrat Sci Ctr Germplasm Creat Western China CHO, Chongqing, Peoples R China
[2] 903 Hosp Joint Logist Support Force Peoples Libera, Dept Orthoped, Hangzhou, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2025年 / 16卷
基金：
中国国家自然科学基金;
关键词：
biopharmaceuticals; nanomedicine; sericin; silk fibroin (SF); wound treatment; SMALL INTERFERING RNA; IN-VITRO; POLYMERIC NANOPARTICLES; EXTRACELLULAR VESICLES; INFLAMMATORY RESPONSES; ULCERATIVE-COLITIS; FIBROIN HYDROGEL; OXIDATIVE STRESS; SERICIN HYDROGEL; BOMBYX-MORI;
D O I：
10.3389/fphar.2025.1548837
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The unique properties of sericin and silk fibroin (SF) favor their widespread application in biopharmaceuticals, particularly in wound treatment and bone repair. The immune response directly influences wound healing cycle, and the extensive immunomodulatory functions of silk-based nanoparticles and hydrogels have attracted wide attention. However, different silk-processing methods may trigger intense immune system resistance after implantation into the body. In this review, we elaborate on the inflammation and immune responses caused by the implantation of sericin and SF and also explore their anti-inflammatory properties and immune regulatory functions. More importantly, we describe the latest research progress in enhancing the immunotherapeutic and anti-inflammatory effects of composite materials prepared from silk from a mechanistic perspective. This review will provide a useful reference for using the correct processes to exploit silk-based biomaterials in different wound treatments.
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页数：20
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