Bioactive Peptides from Milk Proteins with Antioxidant, Anti-Inflammatory, and Antihypertensive Activities

被引:0
作者
Borges, Thais [1 ]
Coelho, Pedro [2 ,3 ]
Prudencio, Cristina [2 ,3 ]
Gomes, Ana [1 ]
Gomes, Paula [1 ]
Ferraz, Ricardo [1 ,2 ,3 ]
机构
[1] Univ Porto, Fac Sci, Dept Chem & Biochem, LAQV REQUIMTE, Rua Campo Alegre,S-N, P-4169007 Porto, Portugal
[2] Polytech Porto, Ctr Translat Hlth & Med Biotechnol Res TBIO, RISE Hlth, ESS, R Dr Antonio Bernardino Almeida 400, P-4200072 Porto, Portugal
[3] Polytech Inst Porto, Sch Hlth ESS, Chem & Biomol Sci, P-4200072 Porto, Portugal
关键词
bioactive peptides; milk proteins; antioxidant; anti-inflammatory; antihypertensive; ANTIMICROBIAL PEPTIDES; COMPREHENSIVE DATABASE; LACTOFERRIN; BOVINE; PROLIFERATION; GLYCOSYLATION; DONKEY; CELLS;
D O I
10.3390/foods14030535
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Background/Objectives: Peptides from protein ingredients exhibit key biological activities, including antimicrobial, antihypertensive, antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Aligning with the One Health approach, there is growing investment in promoting pet health and well-being. As a result, sustainable functional ingredients are increasingly essential for pet food development. In this work, peptides derived from lactoferrins of different mammalian species were synthesized and their antioxidant, anti-inflammatory, and antihypertensive activities were investigated. Methods: This study examined the antioxidant, anti-inflammatory, antihypertensive activities, and cytotoxicity of bioactive peptides derived from lactoferrins of various mammalian species through spectroscopical methods. The peptides were produced via chemical synthesis (bottom-up approach). Results: Peptides derived from bovine lactoferrin showed the most promising antioxidant and anti-inflammatory activities, whereas those derived from human lactoferrin showed the highest antihypertensive effects and the lowest cytotoxicity. In short, milk-derived peptides with antioxidant, anti-inflammatory, and antihypertensive activity were identified. Conclusions: This motivates further studies to better characterize these peptides, including their properties and pharmacokinetics in vivo, to assess their true potential as nutraceutical agents.
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页数:16
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