Congenital malaria in newborns of mothers living in highly endemic parts of Kinshasa, Democratic Republic of Congo

被引：0

作者：

Tshiongo, Japhet Kabalu ^{[1
,2
,3
]}

Kuseke, Lise ^{[1
]}

Tevuzula, Vivi Maketa ^{[1
]}

Luzolo, Flory ^{[1
]}

Kafala, Yann ^{[1
]}

Ngelesi, Evodie ^{[1
]}

Djimde, Moussa ^{[2
,3
,4
]}

Mitashi, Patrick ^{[1
]}

Kalonji-Mukendi, Thierry ^{[5
]}

Nsonizau, Damien Mbanzulu Pita ^{[6
]}

Kayentao, Kassoum ^{[4
]}

Mens, Petra F. ^{[2
,3
]}

van den Bos, Ryan ^{[2
,3
]}

Mavoko, Hypolite Muhindo ^{[1
]}

Schallig, Henk D. F. H. ^{[2
,3
]}

机构：

[1] Univ Kinshasa UNIKIN, Dept Trop Med, Kinshasa, DEM REP CONGO

[2] Amsterdam Univ Med Ctr, Dept Med Microbiol & Infect Prevent, Lab Expt Parasitol, Amsterdam, Netherlands

[3] Amsterdam Univ Med Ctr, Amsterdam Inst Immunol & Infect Dis, Amsterdam, Netherlands

[4] Univ Sci Tech & Technol Bamako USTTB, Malaria Res & Training Ctr MRTC, Bamako, Mali

[5] Minist Sante & PNLMPX FHV, Programme Natl Lutte Contre Monkeypox & Fievres He, Kinshasa, DEM REP CONGO

[6] Univ Kinshasa, Fac Med, Dept Gynecol & Obstet, Kinshasa, DEM REP CONGO

来源：

PAEDIATRICS AND INTERNATIONAL CHILD HEALTH | 2025年

关键词：

Congenital malaria; newborns; pregnant women; diagnosis; Democratic Republic of the Congo; EPIDEMIOLOGY; NIGERIA;

D O I：

10.1080/20469047.2025.2459964

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background Congenital malaria, characterised by low parasitaemia in newborns' peripheral blood, is difficult to diagnose by conventional techniques. Owing to its high sensitivity, polymerase chain reaction (PCR) allows for effective detection of low-density plasmodium infections. This study determined the prevalence of congenital malaria by PCR in newborns of mothers living in a malaria-endemic area of Kinshasa, Democratic Republic of Congo (DRC). Methods A total of 576 mother-newborn pairs were enrolled in two clinical trials in Kinshasa. Maternal peripheral blood was collected at enrolment. At delivery, samples were taken from maternal and newborn peripheral blood, placental blood and placental imprints. Results The prevalence of congenital malaria detected by PCR was 2.4% (14/576) compared with 0.9% (5/576) by microscopy. The prevalence of malaria at delivery was 8.9% (51/570), and placental malaria was 10.6% (59/556) by microscopy. At delivery, maternal malaria was significantly associated with congenital malaria [adjusted odds ratio (aOR) 16.06, 95% CI 2.6-98.5, p < 0.01). Placental malaria also increased the risk of congenital malaria (aOR 5.77, 95% CI 0.9-35.2, p = 0.05). Although 10 of 72 women (16.7%) with placental malaria gave birth to low-weight infants, the association was not statistically significant. Conclusions Although this first assessment of congenital malaria by PCR in DRC found a low prevalence, maternal and placental malaria at delivery were still associated with congenital malaria, highlighting the importance of maternal health in preventing neonatal infections.

引用

页数：8