Associations between depression and anxiety in midlife and dementia more than 30 years later: The HUNT Study

被引：0

作者：

Aunsmo, Ragnhild Holmberg ^{[1
,2
,3
]}

Strand, Bjorn Heine ^{[2
,4
,5
]}

Anstey, Kaarin J. ^{[6
,7
]}

Bergh, Sverre ^{[2
,8
]}

Kivimaki, Mika ^{[9
,10
]}

Kohler, Sebastian ^{[11
,12
]}

Krokstad, Steinar ^{[13
,14
,15
]}

Livingston, Gill ^{[16
]}

Matthews, Fiona E. ^{[17
]}

Selbaek, Geir ^{[1
,2
,4
]}

机构：

[1] Univ Oslo, Inst Clin Med, Fac Med, Pb 1171 Blindern, N-0318 Oslo, Norway

[2] Vestfold Hosp Trust, Norwegian Ctr Ageing & Hlth, Tonsberg, Norway

[3] Innherred Joint Municipal, Verdal, Norway

[4] Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway

[5] Norwegian Inst Publ Hlth, Dept Phys Hlth & Ageing, Oslo, Norway

[6] Univ New South Wales, UNSW Ageing Futures Inst, Sydney, NSW, Australia

[7] Neurosci Res Australia, Res Inst, Randwick, NSW, Australia

[8] Innlandet Hosp Trust, Res Ctr Age Related Funct Decline & Dis, Ottestad, Norway

[9] UCL, Dept Epidemiol & Publ Hlth, London, England

[10] Finnish Inst Occupat Hlth, Ctr Expertise Res & Serv, Helsinki, Finland

[11] Maastricht Univ, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[12] Maastricht Univ, Inst Mental Hlth & Neurosci, Maastricht, Netherlands

[13] Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Nursing, Levanger, Norway

[14] Univ Sci & Technol, Dept Publ Hlth & Nursing, Trondheim, Norway

[15] Levanger Hosp, Nord Trondelag Hosp Trust, Levanger, Norway

[16] UCL, Div Psychiat, London, England

[17] Univ Hull, Inst Clin & Appl Hlth Res, Kingston Upon Hull, England

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2024年 / 16卷 / 04期

基金：

英国惠康基金;

关键词：

Alzheimer's disease; anxiety; association between anxiety and dementia; association between depression and dementia; dementia; depression; depressive symptoms; mental distress; midlife anxiety; midlife anxiety and depression; midlife depression; risk factor for dementia; trajectories; ALZHEIMERS-DISEASE; COGNITIVE DECLINE; INCREASED RISK; SYMPTOMS; LIFE;

D O I：

10.1002/dad2.70036

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: It is unclear how midlife depression and anxiety affect dementia risk. We examined this in a Norwegian cohort followed for 30 years. METHODS: Dementia status at age 70+ in the fourth wave of the Tr & oslash;ndelag Health Study (HUNT4, 2017-2019, N = 9745) was linked with anxiety and depression from HUNT1 (1984-1985), HUNT2 (1995-1997), HUNT3 (2006-2008), and HUNT4. Longitudinal anxiety and depression score, and prevalence trajectories during 1984-2019 by dementia status at HUNT4 were fitted using mixed effects regression adjusting for age, sex, education, and lifestyle and health factors. RESULTS: Dementia at HUNT4 was associated with higher case prevalence at all waves, from 1.9 percentage points (pp) (95% CI: 0.1-3.7) higher at HUNT1 to 7.6 pp (95% CI: 5.7-9.6) higher at HUNT4. DISCUSSION: Our findings show that depression and anxiety was more common more than 30 years before dementia onset in those who later developed dementia.

引用

页数：12

共 51 条

[1] Depression as a modifiable factor to decrease the risk of dementia [J].

Almeida, O. P. ;

Hankey, G. J. ;

Yeap, B. B. ;

Golledge, J. ;

Flicker, L. .

TRANSLATIONAL PSYCHIATRY, 2017, 7 :e1117-e1117

[2] Cohort Profile Update: The HUNT Study, Norway [J].

Asvold, Bjorn Olav ;

Langhammer, Arnulf ;

Rehn, Tommy Aune ;

Kjelvik, Grete ;

Grontvedt, Trond Viggo ;

Sorgjerd, Elin Pettersen ;

Fenstad, Jorn Soberg ;

Heggland, Jon ;

Holmen, Oddgeir ;

Stuifbergen, Maria C. ;

Vikjord, Sigrid Anna Aalberg ;

Brumpton, Ben M. ;

Skjellegrind, Havard Kjesbu ;

Thingstad, Pernille ;

Sund, Erik R. ;

Selbaek, Geir ;

Mork, Paul Jarle ;

Rangul, Vegar ;

Hveem, Kristian ;

Naess, Marit ;

Krokstad, Steinar .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2023, 52 (01) :E80-E91

[3] Does parity matter in women's risk of dementia? A COSMIC collaboration cohort study [J].

Bae, Jong Bin ;

Lipnicki, Darren M. ;

Han, Ji Won ;

Sachdev, Perminder S. ;

Kim, Tae Hui ;

Kwak, Kyung Phil ;

Kim, Bong Jo ;

Kim, Shin Gyeom ;

Kim, Jeong Lan ;

Moon, Seok Woo ;

Park, Joon Hyuk ;

Ryu, Seung-Ho ;

Youn, Jong Chul ;

Lee, Dong Young ;

Lee, Dong Woo ;

Lee, Seok Bum ;

Lee, Jung Jae ;

Jhoo, Jin Hyeong ;

Llibre-Rodriguez, Juan J. ;

Llibre-Guerra, Jorge J. ;

Valhuerdi-Cepero, Adolfo J. ;

Ritchie, Karen ;

Ancelin, Marie-Laure ;

Carriere, Isabelle ;

Skoog, Ingmar ;

Najar, Jenna ;

Sterner, Therese Rydberg ;

Scarmeas, Nikolaos ;

Yannakoulia, Mary ;

Dardiotis, Efthimios ;

Meguro, Kenichi ;

Kasai, Mari ;

Nakamura, Kei ;

Riedel-Heller, Steffi ;

Roehr, Susanne ;

Pabst, Alexander ;

van Boxtel, Martin ;

Kohler, Sebastian ;

Ding, Ding ;

Zhao, Qianhua ;

Liang, Xiaoniu ;

Scazufca, Marcia ;

Lobo, Antonio ;

De-la-Camara, Concepcion ;

Lobo, Elena ;

Kim, Ki Woong .

BMC MEDICINE, 2020, 18 (01)

[4]

Barnes DE, 2012, ARCH GEN PSYCHIAT, V69, P493, DOI 10.1001/archgenpsychiatry.2011.1481

[5] Anxiety as a risk factor of Alzheimer's disease and vascular dementia [J].

Becker, Eva ;

Rios, Claudia Lorena Orellana ;

Lahmann, Claas ;

Ruecker, Gerta ;

Bauer, Joachim ;

Boeker, Martin .

BRITISH JOURNAL OF PSYCHIATRY, 2018, 213 (05) :654-660

[6] Depression and risk of developing dementia [J].

Byers, Amy L. ;

Yaffe, Kristine .

NATURE REVIEWS NEUROLOGY, 2011, 7 (06) :323-331

[7] Treatment-Resistant depression enhances risks of dementia and alzheimer's disease: A nationwide longitudinal study [J].

Chan, Yee-Lam E. ;

Chen, Mu-Hong ;

Tsai, Shih-Jen ;

Bai, Ya-Mei ;

Tsai, Chia-Fen ;

Cheng, Chih-Ming ;

Su, Tung-Ping ;

Chang, Wen-Han ;

Chen, Tzeng-Ji ;

Li, Cheng-Ta .

JOURNAL OF AFFECTIVE DISORDERS, 2020, 274 :806-812

[8] No further research needed: Abandoning the Hospital and Anxiety Depression Scale (HADS) [J].

Coyne, James C. ;

van Sonderen, Eric .

JOURNAL OF PSYCHOSOMATIC RESEARCH, 2012, 72 (03) :173-174

[9] Depression-an underrecognized target for prevention of dementia in Alzheimer's disease [J].

Dafsari, Forugh S. ;

Jessen, Frank .

TRANSLATIONAL PSYCHIATRY, 2020, 10 (01)

[10] Anxiety Is Not Associated with the Risk of Dementia or Cognitive Decline: The Rotterdam Study [J].

de Bruijn, Renee F. A. G. ;

Direk, Nese ;

Mirza, Saira Saeed ;

Hofman, Albert ;

Koudstaal, Peter J. ;

Tiemeier, Henning ;

Ikram, M. Arfan .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2014, 22 (12) :1382-1390

← 1 2 3 4 5 6 →