Prevalence of Retinal Vascular Anomalies in the German Population: Results from the Gutenberg Health Study

被引：0

作者：

Voigt, Anna M. ^{[1
]}

Neubert, Karl ^{[1
]}

Hoh, Stella ^{[1
]}

Haj Ibrahim, Ahmad ^{[1
]}

Wild, Philipp S. ^{[2
,3
,4
,5
]}

Lackner, Karl J. ^{[6
]}

Wicke, Felix S. ^{[7
]}

Schmidtmann, Irene ^{[8
]}

Muenzel, Thomas ^{[9
]}

Tuescher, Oliver ^{[10
,11
]}

Schattenberg, Jorn M. ^{[12
,13
,14
]}

Konstantinides, Stavros V. ^{[3
]}

Pfeiffer, Norbert ^{[1
]}

Schuster, Alexander K. ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Ophthalmol, Langenbeckstr 1, D-55131 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Prevent Cardiol & Prevent Med, Mainz, Germany

[3] Univ Med Ctr Mainz, Ctr Thrombosis & Hemostasis, Mainz, Germany

[4] German Ctr Cardiovasc Res DZHK, Partner Site Rhine Main, Mainz, Germany

[5] Inst Mol Biol IMB, Mainz, Germany

[6] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Clin Chem & Lab Med, Mainz, Germany

[7] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Psychosomat Med & Psychotherapy, Mainz, Germany

[8] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Hlth Serv Res, Mainz, Germany

[9] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Cardiol 1, Mainz, Germany

[10] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Psychiat & Psychotherapy, Mainz, Germany

[11] Leibniz Inst Resilience Res, Mainz, Germany

[12] Univ Med Ctr, Metab Liver Res Ctr, Mainz, Germany

[13] Univ Med Ctr, Med, Mainz, Germany

[14] Saarland Univ, Med Ctr, Dept Internal Med 2, Homburg, Germany

来源：

OPHTHALMIC EPIDEMIOLOGY | 2025年

关键词：

Arterial and venous tortuosity; cilioretinal arteries; epidemiology; myopia; CILIORETINAL ARTERIES; MICROVASCULATURE; TORTUOSITY; CHILDREN; IMPACT; BIRTH; EYES;

D O I：

10.1080/09286586.2024.2442365

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To determine the prevalence of retinal vascular anomalies in the general population in Germany and to analyse potential associations with ocular and systemic factors. Methods: The Gutenberg Health Study is a population-based cohort study, including 15,010 participants aged 35-74 years. We performed fundus photographs of the macula and the optic disc. Vascular anomalies of the retina were graded. The prevalence was computed. We conducted multivariable logistic regression analysis including generalized estimating equations to assess associated factors. Results: We included 12,956 participants (mean age 55.0 +/- 11.1 years; 49.8% female). Retinal arterial tortuosity (RAT) was present in 5.9% in at least one eye and in 3.7% in both eyes. Systolic (OR = 1.01, p = 0.0039) and diastolic (OR = 0.98, p = 0.0039) arterial blood pressure, low-density lipoproteins (LDL) levels (OR = 1.0, p = 0.036), and spherical equivalent (OR = 1.06, p < 0.0001) were associated with RAT. Birth weight (OR = 0.97, p < 0.0001) and age (OR = 0.85, p = 0.0004) were inversely associated, while high-density lipoproteins (HDL), body mass index, and smoking were not associated with RAT. Temporal cilioretinal arteries (CRA) were prevalent in at least one eye in 40.2% and in 9.2% in both eyes. Spherical equivalent was associated with the prevalence of CRA (OR = 1.03 per dpt, p = 0.0006). Branch-building CRA had a prevalence of 0.5% in at least one eye. Conclusion: This study describes prevalence of retinal vascular anomalies for the first time in a German population. CRA were positively associated with spherical equivalent and thus might be protective for myopia. RAT was associated with cardiovascular risk factors and with lower birth weight.

引用

页数：8

共 27 条

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