Recent Advances on Regioselective C-H Borylation of Indoles

被引：2

作者：

Guo, Yanyan ^{[1
]}

Wang, Meiyu ^{[1
]}

Liu, Guodu ^{[1
,2
]}

机构：

[1] Inner Mongolia Univ, Inner Mongolia Key Lab Fine Organ Synth, Coll Chem & Chem Engn, Hohhot 010030, Peoples R China

[2] Inner Mongolia Acad Sci & Technol, Hohhot 010010, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Regioselective borylation; Borylated indoles; Electrophilic C-H borylation; Transition-metal-catalyzed C-H borylation; Chelation effect; 2-SUBSTITUTED INDOLES; CATALYZED BORYLATION; ACTIVATION; REACTIVITY; ARENES;

D O I：

10.1002/ajoc.202400464

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Borylated indoles are versatile building blocks for functional molecules, such as pharmaceutical and natural products. However, the C-H borylation regioselectivity of unprotected indoles with seven distinct sites has been a problem for a long time. Among the various synthetic approaches to borylated indoles, transition-metal-catalyzed, electrophilic C-H borylation and chelation effect directed C-H borylation are attractive methods because of their powerful ability to rapidly construct various C-H borylation of indoles. In this review, we highlight the developments in the C-H borylation regioselectivity of indole using these methods of C-H borylation over the last 20 years. With a focus on the mechanism of the C-H borylation of indole, further studies and developments of this field would be inspired in the future.

引用

页数：19

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