Targeting DKK1 to Remodel the Tumor Microenvironment and Enhance Immune Checkpoint Blockade Therapy

被引:0
|
作者
Shi, Tao [1 ]
Wei, Jia [1 ]
机构
[1] Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp,Med Sch, Dept Oncol, Nanjing, Peoples R China
基金
中国国家自然科学基金;
关键词
PLUS CHEMOTHERAPY; GASTROESOPHAGEAL JUNCTION; SERUM DICKKOPF-1; BIOMARKER; CANCER; ANTAGONIST; DIAGNOSIS; CELLS; LUNG;
D O I
10.1200/JCO-24-01619
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页数:5
相关论文
共 50 条
  • [1] Targeting DKK3 to remodel tumor immune microenvironment and enhance cancer immunotherapy
    Kai Shi
    Yan Zhao
    Hao Ye
    Xiaoming Zhu
    Zhenghai Chen
    BMC Cancer, 25 (1)
  • [2] Targeting the tumor microenvironment to overcome immune checkpoint blockade therapy resistance
    Li, Yaqi
    Liu, Jing
    Gao, Long
    Liu, Yuan
    Meng, Fang
    Li, Xiaoan
    Qin, F. Xiao-Feng
    IMMUNOLOGY LETTERS, 2020, 220 : 88 - 96
  • [3] Bioresponsive and immunotherapeutic nanomaterials to remodel tumor microenvironment for enhanced immune checkpoint blockade
    Fang, Tianxu
    Cao, Xiaona
    Wang, Li
    Chen, Mo
    Deng, Yueyang
    Chen, Guojun
    BIOACTIVE MATERIALS, 2024, 32 : 530 - 542
  • [4] TARGETING DKK1 TO REVERSE IMMUNOSUPPRESSIVE MACROPHAGES AND ENHANCE PD-1 BLOCKADE THERAPY IN GASTRIC CANCER
    Shi, Tao
    Zhang, Yipeng
    Wang, Yue
    Pan, Yunfeng
    Wang, Hanbing
    Luo, Yuting
    Liang, Kaijie
    Liu, Fangcen
    Liu, Qin
    Che, Keying
    Wang, Xuan
    Yu, Lixia
    Liu, Baorui
    Wei, Jia
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A986 - A986
  • [5] Targeting immune checkpoint therapy to the lung tumor microenvironment
    Cohen, Allison S.
    Doligalski, Michael L.
    Zheng, Hong
    Tafreshi, Narges K.
    Estrella, Veronica
    Delva, Nella
    Nguyen, Jonathan
    Beg, Amer
    McLaughlin, Mark L.
    Morse, David L.
    CANCER RESEARCH, 2017, 77
  • [6] Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy
    Pelly, Victoria S.
    Moeini, Agrin
    Roelofsen, Lisanne M.
    Bonavita, Eduardo
    Bell, Charlotte R.
    Hutton, Colin
    Blanco-Gomez, Adrian
    Banyard, Antonia
    Bromley, Christian P.
    Flanagan, Eimear
    Chiang, Shih-Chieh
    Jorgensen, Claus
    Schumacher, Ton N.
    Thommen, Daniela S.
    Zelenay, Santiago
    CANCER DISCOVERY, 2021, 11 (10) : 2602 - 2619
  • [7] Epigenetic Modulation of the Tumor Immune Microenvironment to Potentiate Immune Checkpoint Blockade Therapy
    Menzel, Johannes
    Black, Joshua C.
    CANCER DISCOVERY, 2020, 10 (02) : 179 - 181
  • [8] The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy
    Russell, Bonnie L.
    Sooklal, Selisha A.
    Malindisa, Sibusiso T.
    Daka, Lembelani Jonathan
    Ntwasa, Monde
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [9] Antibody mediated blockade of phosphatidylserine to enhance immune checkpoint blockade by repolarizing immune suppressive mechanisms of the tumor microenvironment.
    Hutchins, Jeff
    Gray, Michael J.
    Huang, Xianming
    Gong, Jian
    Hatch, Michaela M. S.
    Van Nguyen
    Hughes, Christopher C. W.
    Brekken, Rolf A.
    Freimark, Bruce D.
    Gerber, David E.
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [10] Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy
    Lu, Chia-Sing
    Lin, Ching-Wen
    Chang, Ya-Hsuan
    Chen, Hsuan-Yu
    Chung, Wei-Chia
    Lai, Wei-Yun
    Ho, Chao-Chi
    Wang, Tong-Hong
    Chen, Chi-Yuan
    Yeh, Chen-Lin
    Wu, Sean
    Wang, Shu-Ping
    Yang, Pan-Chyr
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (02)