Asthma: An Overview of Pathophysiology, Molecular Mechanisms and Combination Therapy

被引：0
作者：
Sneha, S. [1 ]
Singh, Ekta [2 ]
机构：
[1] Acharya & BM Reddy Coll Pharm, Dept Pharmaceut Chem, Bengaluru 560107, Karnataka, India
[2] Aditya Bangalore Inst Pharm Educ & Res, Bengaluru 560064, Karnataka, India
来源：
CURRENT RESPIRATORY MEDICINE REVIEWS | 2024年
关键词：
Asthma; airway obstruction; lungs; bronchoconstriction; bronchodilator therapy; GENOME-WIDE ASSOCIATION; REGULATORY T-CELLS; MOUSE MODEL; EOSINOPHILIC ASTHMA; GENE POLYMORPHISMS; SIGNALING PATHWAY; TH2; CYTOKINES; HLA-G; EXPRESSION; RECEPTORS;
D O I：
10.2174/011573398X322807241009103428
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Asthma is a chronic inflammatory disorder of the respiratory airways that is characterized by narrowing of airways, wheezing, difficulty in respiration, shortness of breath, stiffness in the chest region, and sometimes cough. In some cases, mucus secretion is enhanced. Several factors precipitate asthma. These factors may contribute individually or collectively to the pathophysiology of asthma. The objective of this review is to compile a detailed description of pathways involved in asthma. This compilation helps provide a better understanding of the disease. The information provided in this review may be used for planning a personalized therapy. Besides pathways, this review includes the current therapy used for asthma management. New combinations of drugs targeting multiple pathways can be developed to better manage the disease.
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页数：17
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共 128 条
[1]   An overview of mast cell pattern recognition receptors [J].
Agier, Justyna ;
Pastwinska, Joanna ;
Brzezinska-Blaszczyk, Ewa .
INFLAMMATION RESEARCH, 2018, 67 (09) :737-746
[2]   Genome-wide association studies for discovery of genes involved in asthma [J].
Akhabir, Loubna ;
Sandford, Andrew J. .
RESPIROLOGY, 2011, 16 (03) :396-406
[3]  
[Anonymous], 2009, Medicine and Science in Sports and Exercise, V41
[4]  
Anthoni M, 2007, INT J BIOL SCI, V3, P477
[5]   Targeting cell signaling in allergic asthma [J].
Athari, Seyyed Shamsadin .
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2019, 4 (1)
[6]   Critical role of Toll-like receptors in pathophysiology of allergic asthma [J].
Athari, Seyyed Shamsadin ;
Athari, Seyyede Masoume ;
Beyzay, Fateme ;
Movassaghi, Masoud ;
Mortaz, Esmaeil ;
Taghavi, Mehdi .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017, 808 :21-27
[7]   Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches - Pulmonary Disease/Asthma [J].
Audousset, Camille ;
McGovern, Toby ;
Martin, James G. .
FRONTIERS IN PHYSIOLOGY, 2021, 12
[8]   Role of tumor necrosis factor alpha in asthma [J].
Babu, KS ;
Davies, DE ;
Holgate, ST .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2004, 24 (04) :583-+
[9]   The role of human mast cells in allergy and asthma [J].
Banafea, Ghalya H. ;
Bakhashab, Sherin ;
Alshaibi, Huda F. ;
Pushparaj, Peter Natesan ;
Rasool, Mahmood .
BIOENGINEERED, 2022, 13 (03) :7049-7064
[10]   Inhaled Corticosteroids [J].
Barnes, Peter J. .
PHARMACEUTICALS, 2010, 3 (03) :514-540
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