Mesoporous Silica Nanoparticles Carrying LigustrazineInhibitMetastatic Properties of Colon Cancer Cells

被引：0
作者：
Shu, Wuying [1 ]
Yi, Chongwen [1 ]
Cheng, Wei [1 ]
Tian, Chang [1 ]
机构：
[1] Dali Univ, Affiliated Hosp 1, Dept Gen Surg, 32 Carlsberg Ave, Dali 671000, Yunnan, Peoples R China
来源：
ANNALS OF CLINICAL AND LABORATORY SCIENCE | 2024年 / 54卷 / 04期
关键词：
mesoporous silicananoparticles; ligustrazine; miR-570; Wnt/beta-catenin; coloncancer; targetedregulation; ORPHAN RECEPTORS RORS; TUMOR-GROWTH; PROLIFERATION; DIFFERENTIATION; INHIBITION; SURVIVAL; ROLES;
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objective. Findingmethods that can interfere withWnt/beta-cateninsignalinghas becomeanimportant research direction in inhibiting coloncancermetastasis. Mesoporous silica nanoparticles canefficientlycarry and releasedrugs.Therefore, combiningligustrazine,miR-570,and mesoporous silicananoparticlesas carriers will provide a theoretical basisfor developmentof new therapeutic strategiesanddrugs.Methods. We herein prepared mesoporous silica-loadedligustrazinenanoparticlesand usedthemto culture HT-29 cells;we observed biologicalbehaviorof HT-29 and explored the levels of miR-570and Wnt2/beta-catenin.Results. Mesoporous silicananoparticlesloadedwith Ligustrazine were successfullyprepared. Ligustrazineinhibitedmetastasis of HT-29 cells.Mesoporous silicananoparticles carrying li-gustrazineincreasedthe expressionof miR-570and reduced Wnt/beta-cateninin HT-29 cells.Moreover,overexpressionof miR-570 inhibitedHT- 29 cancercell metastasis and Wnt/beta-catenininhibitionled toinhibition of HT-29 cell metastasis, whileinhibiting miR-570expressionreversed the effect of mesoporoussilicananoparticlescarrying ligustrazine,thereby accelerating HT-29 cell metastasis.Conclusion. miR-570can inhibit Wnt/beta-cateninexpression.Mesoporous silicananoparticles carrying ligustrazinecan promotemiR-570to inhibitWnt/beta-cateninexpression,leadingto inhibition of HT029cell metastasis
引用
收藏
页码：457 / 465
页数：9
相关论文
共 24 条
  • [1] MicroRNA-570 is a novel regulator of cellular senescence and inflammaging
    Baker, Jonathan R.
    Vuppusetty, Chaitanya
    Colley, Thomas
    Hassibi, Shyreen
    Fenwick, Peter S.
    Donnelly, Louise E.
    Ito, Kazuhiro
    Barnes, Peter J.
    [J]. FASEB JOURNAL, 2019, 33 (02) : 1605 - 1616
  • [2] Adjuvant chemotherapy in resected colon cancer: When, how and how long?
    Gelibter, Alain J.
    Caponnetto, Salvatore
    Urbano, Federica
    Emiliani, Alessandra
    Scagnoli, Simone
    Sirgiovanni, Grazia
    Napoli, Valerio M.
    Cortesi, Enrico
    [J]. SURGICAL ONCOLOGY-OXFORD, 2019, 30 : 100 - 107
  • [3] MEDICINAL PLANTS: THEIR USE IN ANTICANCER TREATMENT
    Greenwell, M.
    Rahman, P. K. S. M.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2015, 6 (10): : 4103 - 4112
  • [4] Haggar Fatima A, 2009, Clin Colon Rectal Surg, V22, P191, DOI 10.1055/s-0029-1242458
  • [5] Tetrandrine Inhibits Wnt/β-Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer
    He, Bai-Cheng
    Gao, Jian-Li
    Zhang, Bing-Qiang
    Luo, Qing
    Shi, Qiong
    Kim, Stephanie H.
    Huang, Enyi
    Gao, Yanhong
    Yang, Ke
    Wagner, Eric R.
    Wang, Linyuan
    Tang, Ni
    Luo, Jinyong
    Liu, Xing
    Li, Mi
    Bi, Yang
    Shen, Jikun
    Luther, Gaurav
    Hu, Ning
    Zhou, Qixin
    Luu, Hue H.
    Haydon, Rex C.
    Zhao, Yingming
    He, Tong-Chuan
    [J]. MOLECULAR PHARMACOLOGY, 2011, 79 (02) : 211 - 219
  • [6] Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation and disease
    Jetten, AM
    Ueda, E
    [J]. CELL DEATH AND DIFFERENTIATION, 2002, 9 (11) : 1167 - 1171
  • [7] Jetten AM, 2006, AD DEV BIOL, V16, P313, DOI 10.1016/S1574-3349(06)16010-X
  • [8] Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model
    Lokeshwar, BL
    Selzer, MG
    Zhu, BQ
    Block, NL
    Golub, LM
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2002, 98 (02) : 297 - 309
  • [9] Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer
    Mamaeva, Veronika
    Rosenholm, Jessica M.
    Bate-Eya, Laurel Tabe
    Bergman, Lotta
    Peuhu, Emilia
    Duchanoy, Alain
    Fortelius, Lina E.
    Landor, Sebastian
    Toivola, Diana M.
    Linden, Mika
    Sahlgren, Cecilia
    [J]. MOLECULAR THERAPY, 2011, 19 (08) : 1538 - 1546
  • [10] Giménez VMM, 2017, THER ADV CARDIO DIS, V11, P133, DOI 10.1177/1753944717692293
123