Human organoids and organ-on-chips in coeliac disease research

被引：0
作者：
Simpson, Hanna L. [1 ]
Smits, Eline [1 ]
Moerkens, Renee [1 ]
Wijmenga, Cisca [1 ]
Mooiweer, Joram [1 ]
Jonkers, Iris H. [1 ]
Withoff, Sebo [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands
来源：
TRENDS IN MOLECULAR MEDICINE | 2025年 / 31卷 / 02期
关键词：
PLURIPOTENT STEM-CELLS; TISSUE TRANSGLUTAMINASE; GLIADIN PEPTIDES; BARRIER FUNCTION; PANETH CELLS; T-CELLS; INTESTINAL PERMEABILITY; EPITHELIAL ORGANOIDS; DUODENAL MICROBIOTA; DNA METHYLATION;
D O I：
10.1016/j.molmed.2024.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Coeliac disease (CeD) is an immune-mediated disorder characterised by gluten triggered inflammation and damage in the small intestine, with lifelong gluten free diet (GFD) as the only treatment. It is a multifactorial disease, involving genetic and environmental susceptibility factors, and its complexity and lack of comprehensive human model systems have hindered understanding of its pathogenesis and development of new treatments. Therefore, it is crucial to establish systems that recapitulate patient genetic background and the interactions between the small intestinal epithelial barrier, immune cells, and environment that contribute to CeD. In this review, we discuss disease complexity, recent advances in stem cell biology, organoids, tissue co-cultures, and organ-on-chip (OoC) systems that facilitate the development of comprehensive human model systems, and model applications in preclinical studies of potential treatments.
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收藏
页码：117 / 137
页数：21
相关论文
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