Promising Natural Remedies for Alzheimer's Disease Therapy

被引：0
作者：
Thawabteh, Amin Mahmood [1 ,2 ]
Ghanem, Aseel Wasel [2 ]
Abumadi, Sara [2 ]
Thaher, Dania [2 ]
Jaghama, Weam [2 ]
Karaman, Donia [3 ]
Karaman, Rafik [3 ,4 ]
机构：
[1] Birzeit Univ, Dept Chem, West Bank, Ramallah 00972, Palestine
[2] Birzeit Univ, Fac Pharm Nursing & Hlth Profess, West Bank, Ramallah 00972, Palestine
[3] Al Quds Univ, Fac Pharm, Pharmaceut Sci Dept, Jerusalem 20002, Palestine
[4] Univ Basilicata, Dept Sci, Via Ateneo Lucano 10, I-85100 Potenza, Italy
来源：
MOLECULES | 2025年 / 30卷 / 04期
关键词：
Alzheimer's disease; anti-amyloid drugs; phytoconstituents; <italic>Ginkgo biloba</italic>; rosemary; BACOPA-MONNIERI; COGNITIVE IMPAIRMENT; DOUBLE-BLIND; EXTRACT; NEUROINFLAMMATION; DEMENTIA; PATHWAY; INFLAMMATION; RESVERATROL; POLYPHENOLS;
D O I：
10.3390/molecules30040922
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study examines the intricacies of Alzheimer's disease (AD), its origins, and the potential advantages of various herbal extracts and natural compounds for enhancing memory and cognitive performance. Future studies into AD treatments are encouraged by the review's demonstration of the effectiveness of phytoconstituents that were extracted from a number of plants. In addition to having many beneficial effects, such as improved cholinergic and cognitive function, herbal medicines are also much less harmful, more readily available, and easier to use than other treatments. They also pass without difficulty through the blood-brain barrier (BBB). This study focused on natural substances and their effects on AD by using academic databases to identify peer-reviewed studies published between 2015 and 2024. According to the literature review, 66 phytoconstituents that were isolated from 21 distinct plants have shown efficacy, which could be encouraging for future research on AD therapies. Since most clinical trials produce contradictory results, the study suggests that larger-scale studies with longer treatment durations are necessary to validate or refute the therapeutic efficacy of herbal AD treatments.
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页数：39
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