Light-Induced Difunctionalization of Alkenes with Polyhaloalkanes and Quinoxalin-2(1H)-ones

被引：1

作者：

Kumar, Vivek ^{[1
]}

Bisoyi, Akash ^{[1
]}

Beevi, V. Fathima ^{[1
]}

Yatham, Veera Reddy ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Sch Chem, Thiruvananthapuram 695551, Kerala, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 22期

关键词：

ALKYL-HALIDES; 1,4-ADDITION; RADICALS; TMSCCL3; AMINES;

D O I：

10.1021/acs.joc.4c02119

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a metal-free light-induced three-component reaction for the synthesis of polychloroalkyl-substituted quinoxalin-2(1H)-ones using commercially available alkenes, polyhalo alkanes, and quinoxalin-2(1H)-ones. Preliminary mechanistic studies suggested the generation of radical intermediates via an EDA-complex, single electron transfer, or halogen atom transfer pathway. Under mild reaction conditions, various alkenes and quinoxalin-2(1H)-ones containing different functional groups are compatible, providing the corresponding polychloroalkyl-substituted quinoxalin-2(1H)-ones in moderate to good yields.

引用

页码：16964 / 16968

页数：5

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