Theoretical framework and emerging challenges of lipid metabolism in cancer

被引：0
作者：
Gu, Qiuying [1 ]
Wang, Yuan [1 ]
Yi, Ping [1 ]
Cheng, Chunming [2 ]
机构：
[1] Chongqing Med Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Chongqing 401120, Peoples R China
[2] Univ Oklahoma, Hlth Sci Ctr, OU Hlth Stephenson Canc Ctr, Dept Oncol Sci, Oklahoma City, OK 73104 USA
来源：
SEMINARS IN CANCER BIOLOGY | 2025年 / 108卷
基金：
中国国家自然科学基金;
关键词：
Lipid metabolism; Tumor metabolism; Cancer; Theoretical framework; Lipid synthesis; Fatty acids; Cholesterol; Inhibitors; Cancer therapy; Cancer treatment; FATTY-ACID SYNTHASE; TUMOR-ASSOCIATED MACROPHAGES; COA DESATURASE 1; DE-NOVO LIPOGENESIS; CELL LUNG-CANCER; PROSTATE-CANCER; BINDING PROTEIN; ANTITUMOR-ACTIVITY; T-CELLS; THERAPEUTIC TARGET;
D O I：
10.1016/j.semcancer.2024.12.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Elevated lipid metabolism is one of hallmarks of malignant tumors. Lipids not only serve as essential structural components of biological membranes but also provide energy and substrates for the proliferation of cancer cells and tumor growth. Cancer cells meet their lipid needs by coordinating the processes of lipid absorption, synthesis, transport, storage, and catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial for scientists to stay informed about the developments of cancer lipid metabolism. In this review, we first discuss relevant concepts and theories or assumptions that help us understand the lipid metabolism and -based cancer therapies. We then systematically summarize the latest advancements in lipid metabolism including new mechanisms, novel targets, and up-to-date pre-clinical and clinical investigations of anti-cancer treatment with lipid metabolism targeted drugs. Finally, we emphasize emerging research directions and therapeutic strategies, and discuss future prospective and emerging challenges. This review aims to provide the latest insights and guidance for research in the field of cancer lipid metabolism.
引用
收藏
页码：48 / 70
页数：23
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