Theoretical framework and emerging challenges of lipid metabolism in cancer

被引：0
作者：
Gu, Qiuying [1 ]
Wang, Yuan [1 ]
Yi, Ping [1 ]
Cheng, Chunming [2 ]
机构：
[1] Chongqing Med Univ, Affiliated Hosp 3, Dept Obstet & Gynecol, Chongqing 401120, Peoples R China
[2] Univ Oklahoma, Hlth Sci Ctr, OU Hlth Stephenson Canc Ctr, Dept Oncol Sci, Oklahoma City, OK 73104 USA
来源：
SEMINARS IN CANCER BIOLOGY | 2025年 / 108卷
基金：
中国国家自然科学基金;
关键词：
Lipid metabolism; Tumor metabolism; Cancer; Theoretical framework; Lipid synthesis; Fatty acids; Cholesterol; Inhibitors; Cancer therapy; Cancer treatment; FATTY-ACID SYNTHASE; TUMOR-ASSOCIATED MACROPHAGES; COA DESATURASE 1; DE-NOVO LIPOGENESIS; CELL LUNG-CANCER; PROSTATE-CANCER; BINDING PROTEIN; ANTITUMOR-ACTIVITY; T-CELLS; THERAPEUTIC TARGET;
D O I：
10.1016/j.semcancer.2024.12.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Elevated lipid metabolism is one of hallmarks of malignant tumors. Lipids not only serve as essential structural components of biological membranes but also provide energy and substrates for the proliferation of cancer cells and tumor growth. Cancer cells meet their lipid needs by coordinating the processes of lipid absorption, synthesis, transport, storage, and catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial for scientists to stay informed about the developments of cancer lipid metabolism. In this review, we first discuss relevant concepts and theories or assumptions that help us understand the lipid metabolism and -based cancer therapies. We then systematically summarize the latest advancements in lipid metabolism including new mechanisms, novel targets, and up-to-date pre-clinical and clinical investigations of anti-cancer treatment with lipid metabolism targeted drugs. Finally, we emphasize emerging research directions and therapeutic strategies, and discuss future prospective and emerging challenges. This review aims to provide the latest insights and guidance for research in the field of cancer lipid metabolism.
引用
收藏
页码：48 / 70
页数：23
相关论文
共 525 条
  • [1] Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation
    Abdelwahed, Khaldoun S.
    Siddique, Abu Bakar
    Ebrahim, Hassan Y.
    Qusa, Mohammed H.
    Mudhish, Ethar A.
    Rad, Ashkan H.
    Zerfaoui, Mourad
    Abd Elmageed, Zakaria Y.
    El Sayed, Khalid A.
    [J]. MARINE DRUGS, 2023, 21 (04)
  • [2] PCSK9 Axis-Targeting Pseurotin A as a Novel Prostate Cancer Recurrence Suppressor Lead
    Abdelwahed, Khaldoun S.
    Siddique, Abu Bakar
    Qusa, Mohammed H.
    King, Judy Ann
    Souid, Soumaya
    Abd Elmageed, Zakaria Y.
    El Sayed, Khalid A.
    [J]. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2021, 4 (06) : 1771 - 1781
  • [3] Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor
    Abdelwahed, Khaldoun S.
    Siddique, Abu Bakar
    Mohyeldin, Mohamed M.
    Qusa, Mohammed H.
    Goda, Amira A.
    Singh, Sitanshu S.
    Ayoub, Nehad M.
    King, Judy Ann
    Jois, Seetharama D.
    El Sayed, Khalid A.
    [J]. PHARMACOLOGICAL RESEARCH, 2020, 158
  • [4] Fatty acid transport proteins (FATPs) in cancer
    Acharya, Ranjitha
    Shetty, Shilpa S.
    Kumari, N. Suchetha
    [J]. CHEMISTRY AND PHYSICS OF LIPIDS, 2023, 250
  • [5] Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy
    Adeshakin, Adeleye Oluwatosin
    Liu, Wan
    Adeshakin, Funmilayo O.
    Afolabi, Lukman O.
    Zhang, Mengqi
    Zhang, Guizhong
    Wang, Lulu
    Li, Zhihuan
    Lin, Lilong
    Cao, Qin
    Yan, Dehong
    Wan, Xiaochun
    [J]. CELLULAR IMMUNOLOGY, 2021, 362
  • [6] The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas
    Agostini, Michelle
    Almeida, Luciana Y.
    Bastos, Debora C.
    Ortega, Rose M.
    Moreira, Fernanda S.
    Seguin, Fabiana
    Zecchin, Karina G.
    Raposo, Helena F.
    Oliveira, Helena C. F.
    Amoedo, Nivea D.
    Salo, Tuula
    Coletta, Ricardo D.
    Graner, Edgard
    [J]. MOLECULAR CANCER THERAPEUTICS, 2014, 13 (03) : 585 - 595
  • [7] Metabolomic Rewiring Promotes Endocrine Therapy Resistance in Breast Cancer
    Ahn, Songyeon
    Park, Jun Hyoung
    Grimm, Sandra L.
    Piyarathna, Danthasinghe Waduge Badrajee
    Samanta, Tagari
    Putluri, Vasanta
    Mezquita, Dereck
    Fuqua, Suzanne A. W.
    Putluri, Nagireddy
    Coarfa, Cristian
    Kaipparettu, Benny Abraham
    [J]. CANCER RESEARCH, 2024, 84 (02) : 291 - 304
  • [8] Fatty acid oxidation is associated with proliferation and prognosis in breast and other cancers
    Aiderus, Aziz
    Black, Michael A.
    Dunbier, Anita K.
    [J]. BMC CANCER, 2018, 18
  • [9] The inhibition of autophagy by spautin boosts the anticancer activity of fingolimod in multidrug-resistant hepatocellular carcinoma
    Alhamad, Dima W.
    Elgendy, Sara M.
    Hersi, Fatema
    El-Seedi, Hesham R.
    Omar, Hany A.
    [J]. LIFE SCIENCES, 2022, 304
  • [10] Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer
    Almanza, Aitor
    Mnich, Katarzyna
    Blomme, Arnaud
    Robinson, Claire M.
    Rodriguez-Blanco, Giovanny
    Kierszniowska, Sylwia
    McGrath, Eoghan P.
    Le Gallo, Matthieu
    Pilalis, Eleftherios
    Swinnen, Johannes, V
    Chatziioannou, Aristotelis
    Chevet, Eric
    Gorman, Adrienne M.
    Samali, Afshin
    [J]. NATURE COMMUNICATIONS, 2022, 13 (01)
12345678910