Postradiotherapy Response Assessment Using 18F-FDG PET/CT in Salivary Gland Carcinoma-A Multicenter Study

被引:0
作者
Chen, Po-Yuan [1 ]
Cheng, Nai-Ming [2 ,3 ,4 ]
Lin, Chien-Yu [1 ]
Chang, Kai-Ping [5 ]
Lu, Yi-An [6 ]
Tsai, Tsung-You [6 ]
Chen, Miao-Fen [1 ,7 ]
Fang, Fu-Min [8 ,9 ]
Hsu, Cheng-Lung [10 ]
Hsieh, Rodney Cheng-En [1 ,3 ,11 ,12 ]
机构
[1] Chang Gung Univ, Chang Gung Mem Hosp Linkou, Radiat Oncol, Taoyuan, Taiwan
[2] Chang Gung Mem Hosp Linkou, Nucl Med & Mol Imaging Ctr, Taoyuan, Taiwan
[3] Chang Gung Univ, 5 Fuxing St, Taoyuan 333, Taiwan
[4] Chang Gung Mem Hosp Keelung, Nucl Med, Keelung, Taiwan
[5] Chang Gung Mem Hosp Linkou, Otorhinolaryngol Head & Neck Surg, Taoyuan, Taiwan
[6] Chang Gung Mem Hosp Linkou, Otorhinolaryngol, Taoyuan, Taiwan
[7] Chang Gung Mem Hosp Chiayi, Radiat Oncol, Chiayi, Taiwan
[8] Chang Gung Mem Hosp Kaohsiung, Radiat Oncol, Kaohsiung, Taiwan
[9] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan
[10] Chang Gung Mem Hosp Linkou, Med Oncol, Taoyuan, Taiwan
[11] Chang Gung Mem Hosp Linkou, Med Imaging & Radiol Sci, Taoyuan, Taiwan
[12] Chang Gung Mem Hosp Linkou, Canc Genome Res Ctr, Taoyuan, Taiwan
关键词
F-18-FDG PET; radiation therapy; salivary gland cancer; SUV; treatment response; SQUAMOUS-CELL CARCINOMA; PRIMARY TUMOR SUVMAX; 2ND PRIMARY-CANCER; FDG-PET/CT; POSTOPERATIVE RADIOTHERAPY; RADIATION-THERAPY; DENMARK; 1990-2005; MALIGNANT-TUMORS; PROGNOSTIC VALUE; 18F-FDG PET/CT;
D O I
10.1097/RLU.0000000000005538
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: This multicenter study investigates the efficacy of F-18-FDG PET/CT in postradiotherapy (post-RT) response evaluation in salivary gland carcinoma (SGC). Methods: We retrospectively reviewed 115 SGC patients who underwent definitive or adjuvant RT followed by F-18-FDG PET/CT between 2004 and 2021. Most tumors were parotid gland malignancies (50%). The most common histological subtypes were adenoid cystic (29%) and mucoepidermoid carcinomas (18%). Results: The median follow-up was 65 months. Post-RT anatomic images (CT/MRI) revealed complete response (CR) in 51 patients (44%). Among 53 patients with partial response or stable disease, only 17 (32%) patients experienced locoregional recurrence, with a 5-year locoregional control rate of 69%. Post-RT F-18-FDG PET/CT documented metabolic CR in 81 patients (70%). Metabolic complete responders had significantly higher 5-year locoregional control (90% vs 43%), distant metastasis-free survival (80% vs 48%), progression-free survival (76% vs 24%), and overall survival rates (89% vs 42%) compared with non-complete responders (all P < 0.001), as confirmed in both univariate and multivariate analyses. It identified additional viable tumors in 18 cases (16%) and facilitated salvage local therapies in 7 patients (6%). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of post-RT F-18-FDG PET/CT were 63%, 91%, 70%, 88%, and 84%, respectively, in predicting locoregional recurrence. F-18-FDG PET/CT showed significantly higher sensitivity (88% vs 36%, P = 0.011) in tumors with pre-RT SUVmax >= 7.39 compared with those with SUVmax <7.39. Conclusions: Post-RT F-18-FDG PET/CT demonstrates high negative predictive value and specificity, with metabolic CR predicting excellent outcomes. Additionally, it exhibits higher sensitivity for high-SUVmax SGC, facilitating early detection of viable tumors.
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页码:e68 / e79
页数:12
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