Recent Molecular Epidemiology of Echovirus 11 Throughout North and West Africa Resulted in the First Identification of a Recombinant Strain from an Acute Flaccid Paralysis Case in West Africa

被引：0

作者：

Ndiaye, Ndack ^{[1
]}

Thiaw, Fatou Diene ^{[1
]}

Lagare, Adamou ^{[2
]}

Sinare, Therese ^{[3
]}

Diakite, Mohamed Lemine ^{[4
]}

Ngom, Serigne Fallou Mbacke ^{[1
]}

Kebe, Ousmane ^{[1
]}

Abdoulkader, Issifi Kollo ^{[2
]}

Cisse, Gassim ^{[5
]}

Dia, Mohamed ^{[1
]}

Djimadoum, Hermann Nodji ^{[6
]}

Neya, Christelle Ouedraogo ^{[3
]}

Boubakar, Rakia ^{[2
]}

Ouedraogo, Issaka ^{[3
]}

Essoya, Landoh Dadja ^{[7
]}

Dia, Ndongo ^{[1
]}

Sall, Amadou Alpha ^{[1
]}

Faye, Ousmane ^{[1
]}

Faye, Martin ^{[1
]}

机构：

[1] Inst Pasteur, Virol Dept, 36 Ave Pasteur, Dakar 220, Senegal

[2] Ctr Rech Med & Sanitaire CERMES, 634 Bd Nation, Niamey YN034, Niger

[3] Minist Hlth & Publ Hyg Burkina Faso, Ouagadougou, Kadiogo, Burkina Faso

[4] Minist Hlth Mauritania, Ave Gamel Abdel, Nouakchott, Mauritania

[5] Minist Hlth & Publ Hyg Guinea, G77P56P Blvd Commerce, Conakry 585, Guinea

[6] WHO Country Off Mauritania, ILOT K 140-141 Tevragh Zeina, Nouakchott, Mauritania

[7] WHO, Country Off Guinea, G8Q8JC6, Conakry 817, Guinea

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 11期

关键词：

enterovirus; echovirus E11; genomic sequencing; recombination; phylogeography; West Africa; UNITED-STATES; ENTEROVIRUS; INFECTION; VIRUS; SURVEILLANCE; PATHOGENESIS; DIVERSITY; EVOLUTION; SEQUENCES; PATTERNS;

D O I：

10.3390/v16111772

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Echovirus 11 has emerged as a major public health concern, causing sepsis in neonates in many European countries in recent years. In Africa, especially West Africa, where resources and diagnostic capacities are limited, only sporadic cases have been reported. To better understand the recent molecular epidemiology of E11 in West Africa, we characterized twenty-three echovirus 11 strains isolated through the acute flaccid paralysis and environmental surveillance systems for polio from 2013 to 2023, using high-throughput sequencing. Our data are noteworthy due to identifying for the first time a recombinant strain from an acute flaccid paralysis case and represent the first focus to date on molecular characterization of echovirus 11 in West Africa. Moreover, our data show that echovirus 11 diverged from 1970 (95% HPD range, 1961-1979) and evolved into four distinct clades, with the virus spread from West Africa to Europe, exhibiting two introductions in France around 2017, from Senegal and Guinea. Furthermore, the in silico analysis reveals four non-conservative amino acid substitutions in the VP1 sequences of the European strains associated with neonatal sepsis in newborns and a conserved amino acid motif in the VP1 protein toward enterovirus genotypes. Our data provide new insights into the epidemiology of echovirus 11 and point to the crucial need to implement specific surveillance programs targeting non-polio enteroviruses for the rapid identification of emerging or re-emerging enterovirus species, particularly in Africa.

引用

页数：16