Divergent Synthesis of Silacycles by Ligand-Controlled Rhodium-Catalyzed Annulation of (2-Hydrosilylaryl)acetylenes

被引：0

作者：

Fuji, Kazuto ^{[2
]}

Kawashima, Kyohei ^{[1
]}

Mori, Toshifumi ^{[1
,2
]}

Sekine, Kohei ^{[1
,2
]}

Kuninobu, Yoichiro ^{[1
,2
]}

机构：

[1] Kyushu Univ, Inst Mat Chem & Engn, 6-1 Kasugakoen, Kasuga Shi, Fukuoka 8168580, Japan

[2] Kyushu Univ, Interdisciplinary Grad Sch Engn Sci, Dept Interdisciplinary Engn Sci, Kasuga Shi, Fukuoka 8168580, Japan

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 07期

关键词：

HYDRIDE-PROMOTED CYCLIZATION; TRANS-HYDROSILYLATION; ALKYNES; BENZOSILOLES; HETEROCYCLES; DERIVATIVES; SITE;

D O I：

10.1021/acs.orglett.4c04694

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study demonstrates the rhodium-catalyzed divergent synthesis of 5-, 5,6-, and 8-membered silacyclic compounds, such as benzosilole, silolosiline, and disilocine, from (2-hydrosilylaryl)acetylenes. To achieve high product selectivity, intra- and intermolecular reactions are controlled by tuning the mono- and bidentate phosphine ligands on the rhodium catalyst precursor. Deuterium labeling experiments and computational studies reveal that the annulation reaction proceeds via hydride transfer to the alkyne moiety.

引用

页码：1614 / 1619

页数：6

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