Anti-atherogenic properties of Plectranthus glandulosus Hook. F. (Lamiaceae) leaves through lipid profile regulation, oxidative stress reduction, and aorta media thickening attenuation in high-fat diet-fed Sprague-Dawley rats

被引：0

作者：

Zouheira, Djamila ^{[1
]}

Kajal, Anu ^{[2
]}

Nchouwet, Moise Legentil ^{[3
]}

Kamani, Sylviane Laure Poualeu ^{[3
]}

Yamthe, Lauve Rachel Tchokouaha ^{[1
]}

Agbor, Gabriel Agbor ^{[1
]}

Ngnokam, Sylvie Lea Wansi ^{[3
]}

Singh, Randhir ^{[4
]}

机构：

[1] Inst Med Res & Med Plants Studies, Ctr Res Med Plants & Tradit Med, Yaounde, Cameroon

[2] Maharishi Markandeshwar Deemed be Univ, Dept Pharmaceut Sci, Mullana, India

[3] Univ Dschang, Fac Sci, Dept Anim Biol, Dschang, Cameroon

[4] Cent Univ Punjab, Sch Hlth Sci, Dept Pharmacol, Bathinda, India

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2025年

关键词：

Anti-atherogenic; Plectranthus glandulosus; hyperlipidaemia; oxidative stress; aorta media thickening; ATHEROSCLEROSIS; HYPERLIPIDEMIA; RESISTANCE; CATALASE;

D O I：

10.1080/13813455.2025.2476644

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study investigated the anti-atherogenic effects of Plectranthus glandulosus leaves aqueous, hydro-ethanolic extracts, and ethyl acetate fraction at doses of 100, 200, and 400 mg/kg for 21 d. As results, at the dose of 400 mg/kg, the ethyl acetate fraction significantly (p < .001) decreased the level of total cholesterol (112.52 +/- 1.21 mg/dL), triglyceride (76.47 +/- 0.97 mg/dL), and LDL-C (22.01 +/- 2.92 mg/dL). Whereas, a significant (p < .001) increase was observed in the level of HDL-C (74.97 +/- 1.99 mg/dL). Moreover, the atherogenic index significantly (p < .001) decreased (0.008 +/- 0.00 mg/dL), while the percentage of atherogenic protection increased (99.13 +/- 0.78%). The activity of antioxidant enzymes increased significantly (p < .001), while malondialdehyde concentration decreased. The thickening of aorta media (67.27 +/- 7.15 mu m) was also attenuated significantly (p < .001). Thus, our finding supports the use of Plectranthus glandulosus for future atherosclerosis drug discovery.

引用

页数：15