Methotrexate - Safe Backbone for the Treatment of Rheumatoid Arthritis

被引：0
作者：
Krasselt, Marco [1 ]
机构：
[1] Univ Leipzig, Med Clic 3, Med Ctr, Dept Endocrinol Nephrol & Rheumatol, Liebigstr 20, D-04103 Leipzig, Germany
来源：
CURRENT RHEUMATOLOGY REVIEWS | 2025年 / 21卷 / 02期
关键词：
Methotrexate; MTX; rheumatoid arthritis; safety; folic acid; intoxication; LOW-DOSE METHOTREXATE; INTERSTITIAL LUNG-DISEASE; FOLIC-ACID; TRIMETHOPRIM-SULFAMETHOXAZOLE; SUBCUTANEOUS METHOTREXATE; CAFFEINE CONSUMPTION; ORAL METHOTREXATE; DRUG-INTERACTIONS; CONCOMITANT USE; ADVERSE EVENTS;
D O I：
10.2174/0115733971317122240626053727
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Methotrexate (MTX) is the primarily used disease-modifying antirheumatic drug (DMARD) for the treatment of Rheumatoid Arthritis (RA). MTX is a safe agent, even when used for years - provided that treatment is regularly monitored and prescribers follow some simple rules, such as prescribing tablets of a single strength only. Proper patient education contributes greatly to safe treatment. The knowledge of important pharmacologic facts, possible interactions, and clinical warning signs also helps to prevent or recognize intoxications early.Therefore, this review addresses key aspects regarding the safety of MTX. In this respect, it includes adverse events, possible interactions with frequently used drugs and details on the rare but life-threatening intoxication, e.g., due to erroneous daily intake.
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页码：169 / 181
页数：13
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