Diagnosis and treatment of perioperative anaemia in elective primary hip and knee arthroplasty Consensus statement of the "Committee for Perioperative Management" of the Working Group for Endoprosthetics

Background: Hip and knee arthroplasty remain risk procedures for bleeding complications. The prevalence of preoperative anaemia prior to elective joint replacement is high. There are no standardized guidelines in Germany for the diagnosis and treatment of perioperative anaemia in elective hip and knee arthroplasty. The aim of this work, initiated by the "Perioperative Management" committee of the German Society for Endoprosthetics (AE), was to develop a treatment recommendation. Materials and methods: A systematic review of relevant publications between 2010 and 2023 was conducted. Medline, the Cochrane Library, existing national and international guidelines, and recommendations from other professional societies were considered. A total of 38 relevant articles were identified. Questions with clinical relevance were prepared in advance by the committee, and these were answered after studying and evaluating the literature. Finally, a recommendation was determined by expert consensus using the GRADE system. Consensus: All patients scheduled for elective joint replacement should undergo preoperative diagnostics. Preoperative anaemia is a risk factor for increased mortality and the likelihood of transfusions; therefore, the cause of anaemia should be investigated preoperatively and treated accordingly. The administration of iron should be considered in diagnosed iron deficiency and can be done either orally or intravenously. Oral substitution therapy should be started 3 months preoperatively. Intravenous therapy requires less time, causes fewer side effects and should be administered 4 weeks preoperatively. Persistent iron deficiency anaemia despite substitution, anaemia due to chronic inflammation and renal anaemia may indicate the need for erythropoietin substitution.