Unraveling the tumor-initiating cells in hepatocellular carcinoma

被引：0
作者：
Tsui, Yu Man [1 ,2 ]
Ho, Daniel Wai-Hung [1 ,2 ]
Ng, Irene Oi-Lin [1 ,2 ]
机构：
[1] Univ Hong Kong, Dept Pathol, Hong Kong, Peoples R China
[2] Univ Hong Kong, State Key Lab Liver Res, Hong Kong, Peoples R China
来源：
CANCER CELL | 2024年 / 42卷 / 12期
关键词：
STEM-CELLS;
D O I：
10.1016/j.ccell.2024.10.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aggressive features of hepatocellular carcinoma (HCC) are highly related to liver tumor-initiating cells (TICs), which are heterogeneous and plastic. In this issue of Cancer Cell, Yang et al. reveal the ability of CD49f-high TICs in shaping the tumor immunosuppressive microenvironment in HCC.
引用
收藏
页码：1990 / 1993
页数：4
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[1]   Melanoma Stem Cells Educate Neutrophils to Support Cancer Progression [J].
Anselmi, Martina ;
Fontana, Fabrizio ;
Marzagalli, Monica ;
Gagliano, Nicoletta ;
Sommariva, Michele ;
Limonta, Patrizia .
CANCERS, 2022, 14 (14)
[2]   Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice [J].
Chiu, David Kung-Chun ;
Yuen, Vincent Wai-Hin ;
Cheu, Jacinth Wing-Sum ;
Wei, Larry Lai ;
Ting, Vox ;
Fehlings, Michael ;
Sumatoh, Hermi ;
Nardin, Alessandra ;
Newell, Evan W. ;
Ng, Irene Oi-Lin ;
Yau, Thomas Chung-Cheung ;
Wong, Chun-Ming ;
Wong, Carmen Chak-Lui .
GASTROENTEROLOGY, 2020, 159 (02) :609-623
[3]   Immunotherapy for targeting cancer stem cells in hepatocellular carcinoma [J].
Dai, Xiaomeng ;
Guo, Yixuan ;
Hu, Yan ;
Bao, Xuanwen ;
Zhu, Xudong ;
Fu, Qihan ;
Zhang, Hangyu ;
Tong, Zhou ;
Liu, Lulu ;
Zheng, Yi ;
Zhao, Peng ;
Fang, Weijia .
THERANOSTICS, 2021, 11 (07) :3489-3501
[4]   Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma [J].
Ho, Daniel Wai-Hung ;
Tsui, Yu-Man ;
Chan, Lo-Kong ;
Sze, Karen Man-Fong ;
Zhang, Xin ;
Cheu, Jacinth Wing-Sum ;
Chiu, Yung-Tuen ;
Lee, Joyce Man-Fong ;
Chan, Albert Chi-Yan ;
Cheung, Elaine Tin-Yan ;
Yau, Derek Tsz-Wai ;
Chia, Nam-Hung ;
Lo, Irene Lai-Oi ;
Sham, Pak-Chung ;
Cheung, Tan-To ;
Wong, Carmen Chak-Lui ;
Ng, Irene Oi-Lin .
NATURE COMMUNICATIONS, 2021, 12 (01)
[5]   LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress [J].
Huang, Hongyang ;
Tsui, Yu-Man ;
Ho, Daniel Wai-Hung ;
Chung, Clive Yik-Sham ;
Sze, Karen Man-Fong ;
Lee, Eva ;
Cheung, Gary Cheuk-Hang ;
Zhang, Vanilla Xin ;
Wang, Xia ;
Lyu, Xueying ;
Ng, Irene Oi-Lin .
HEPATOLOGY, 2024, 79 (02) :323-340
[6]   Cancer stem cells in hepatocellular carcinoma - from origin to clinical implications [J].
Lee, Terence Kin-Wah ;
Guan, Xin-Yuan ;
Ma, Stephanie .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2022, 19 (01) :26-44
[7]   Neutrophil profiling illuminates anti-tumor antigen-presenting potency [J].
Wu, Yingcheng ;
Ma, Jiaqiang ;
Yang, Xupeng ;
Nan, Fang ;
Zhang, Tiancheng ;
Ji, Shuyi ;
Rao, Dongning ;
Feng, Hua ;
Gao, Ke ;
Gu, Xixi ;
Jiang, Shan ;
Song, Guohe ;
Pan, Jiaomeng ;
Zhang, Mao ;
Xu, Yanan ;
Zhang, Shu ;
Fan, Yihui ;
Wang, Xiaoying ;
Zhou, Jian ;
Yang, Li ;
Fan, Jia ;
Zhang, Xiaoming ;
Gao, Qiang .
CELL, 2024, 187 (06) :1422-1439.e24
[8]   Liver tumour immune microenvironment subtypes and neutrophil heterogeneity [J].
Xue, Ruidong ;
Zhang, Qiming ;
Cao, Qi ;
Kong, Ruirui ;
Xiang, Xiao ;
Liu, Hengkang ;
Feng, Mei ;
Wang, Fangyanni ;
Cheng, Jinghui ;
Li, Zhao ;
Zhan, Qimin ;
Deng, Mi ;
Zhu, Jiye ;
Zhang, Zemin ;
Zhang, Ning .
NATURE, 2022, 612 (7938) :141-+
[9]   Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy [J].
Yang, Chen ;
Geng, Haigang ;
Yang, Xupeng ;
Ji, Shuyi ;
Liu, Zhicheng ;
Feng, Hao ;
Li, Qian ;
Zhang, Tangansu ;
Zhang, Sisi ;
Ma, Xuhui ;
Zhu, Chuchen ;
Xu, Nuo ;
Xia, Yuhan ;
Li, Yan ;
Wang, Hongye ;
Yu, Chune ;
Du, Shangce ;
Miao, Beiping ;
Xu, Lei ;
Wang, Hui ;
Cao, Ying ;
Li, Botai ;
Zhu, Lili ;
Tang, Xiangyu ;
Zhang, Haoyu ;
Zhu, Chunchao ;
Huang, Zhao ;
Leng, Chao ;
Hu, Haiyan ;
Chen, Xiaoping ;
Yuan, Shengxian ;
Jin, Guangzhi ;
Bernards, Rene ;
Sun, Chong ;
Zheng, Quan ;
Qin, Wenxin ;
Gao, Qiang ;
Wang, Cun .
CANCER CELL, 2024, 42 (12) :2064-2081.e19
[10]   Reciprocal interactions between malignant cells and macrophages enhance cancer stemness and M2 polarization in HBV-associated hepatocellular carcinoma [J].
Zhang, Qingyang ;
Tsui, Yu-Man ;
Zhang, Vanilla Xin ;
Lu, Anna Jingyi ;
Lee, Joyce Man-Fong ;
Lee, Eva ;
Cheung, Gary Cheuk-Hang ;
Li, Po -Man ;
Cheung, Elaine Tin-Yan ;
Chia, Nam-Hung ;
Lo, Irene Lai-Oi ;
Chan, Albert Chi-Yan ;
Cheung, Tan-To ;
Ng, Irene Oi-Lin ;
Ho, Daniel Wai-Hung .
THERANOSTICS, 2024, 14 (02) :892-910
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