Visual and Auditory Sensory Impairments Differentially Relate with Alzheimer's Pathology

被引：0

作者：

Byeon, Gihwan ^{[1
]}

Byun, Min Soo ^{[2
,3
]}

Yi, Dahyun ^{[4
]}

Jung, Joon Hyung ^{[5
]}

Kong, Nayeong ^{[2
]}

Chang, Yoonyoung ^{[2
]}

Keum, Musung ^{[2
]}

Jung, Gijung ^{[4
]}

Ahn, Hyejin ^{[4
]}

Lee, Jun-Young ^{[6
]}

Kim, Yu Kyeong ^{[7
]}

Kang, Koung Mi ^{[8
]}

Sohn, Chul-Ho ^{[8
]}

Lee, Dong Young ^{[2
,3
,4
]}

机构：

[1] Kangwon Natl Univ Hosp, Dept Neuropsychiat, Chunchon, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Psychiat, 101 Daehak Ro, Seoul 03080, South Korea

[3] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea

[4] Seoul Natl Univ, Med Res Ctr, Inst Human Behav Med, Seoul, South Korea

[5] Chungbuk Natl Univ Hosp, Dept Psychiat, Cheongju, South Korea

[6] SMG SNU Boramae Med Ctr, Dept Neuropsychiat, Seoul, South Korea

[7] SMG SNU Boramae Med Ctr, Dept Nucl Med, Seoul, South Korea

[8] Seoul Natl Univ Hosp, Dept Radiol, Seoul, South Korea

来源：

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | 2024年 / 22卷 / 04期

关键词：

KEY WORDS: Dementia; Sensation disorders; Alzheimer disease; Amyloid; NEUROPSYCHOLOGICAL ASSESSMENT BATTERY; HEARING-LOSS; COGNITIVE IMPAIRMENT; KOREAN VERSION; TOTAL SCORES; DISEASE; BRAIN; DEMENTIA; ASSOCIATION; HOMOCYSTEINE;

D O I：

10.9758/cpn.24.1169

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: We intended to investigate the relationships between visual sensory impairment (VSI) or auditory sensory impairment (ASI) and brain pathological changes associated with cognitive decline in older adults. Methods: We primarily tried to examine whether each sensory impairment is related to Alzheimer's disease (AD) pathology, specifically beta-amyloid (A(3) deposition, through both cross-sectional and longitudinal approaches in cognitively unimpaired older adults. Self-report questionnaires on vision and hearing status were administered at the baseline. Neuroimaging scans including brain [11C] Pittsburgh Compound B PET and MRI, as well as clinical assessments, were performed at baseline and 2-year follow-up. Results: Cross-sectional analyses showed that the VSI-positive group had significantly higher A(3 deposition than the VSI-negative group, whereas there was no significant association between ASI positivity and A(3 deposition. Longitudinal analyses revealed that VSI positivity at baseline was significantly associated with increased A(3 deposition over 2 years ((3 = 0.153, p = 0.025), although ASI positivity was not ((3 = 0.045, p = 0.518). VSI positivity at baseline was also significantly associated with greater atrophic changes in AD-related brain regions over the 2-year follow-up period ((3 = -0.207, p = 0.005), whereas ASI positivity was not ((3 = 0.024, p = 0.753). Neither VSI nor ASI positivity was related to cerebrovascular injury, as measured based on the white matter hyperintensity volume. Conclusion: The findings suggest that VSI is probably related to AD-specific pathological changes, which possibly mediate the reported relationship between VSI and cognitive decline. In contrast, ASI appears not associated with AD pathologies but may contribute to cognitive decline via other mechanisms.

引用

页码：610 / 623

页数：14

共 57 条

[1] Crews JE, Campbell VA., Vision impairment and hearing loss among community-dwelling older Americans: implications for health and functioning, Am J Public Health, 94, pp. 823-829, (2004)
[2] Heine C, Browning CJ, Gong CH., Sensory loss in China: prevalence, use of aids, and impacts on social participation, Front Public Health, 7, (2019)
[3] Davies-Kershaw HR, Hackett RA, Cadar D, Herbert A, Orrell M, Steptoe A., Vision impairment and risk of dementia: findings from the English longitudinal study of ageing, J Am Geriatr Soc, 66, pp. 1823-1829, (2018)
[4] Ward ME, Gelfand JM, Lui LY, Ou Y, Green AJ, Stone K, Et al., Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment, Ann Neurol, 83, pp. 730-738, (2018)
[5] Davies HR, Cadar D, Herbert A, Orrell M, Steptoe A., Hearing impairment and incident dementia: findings from the English longitudinal study of ageing, J Am Geriatr Soc, 65, pp. 2074-2081, (2017)
[6] Lin FR, Yaffe K, Xia J, Xue QL, Harris TB, Purchase-Helzner E, Et al., Hearing loss and cognitive decline in older adults, JAMA Intern Med, 173, pp. 293-299, (2013)
[7] Byeon G, Oh GH, Jhoo JH, Jang JW, Bae JB, Han JW, Et al., Dual sensory impairment and cognitive impairment in the Korean longitudinal elderly cohort, Neurology, 96, pp. e2284-e2295, (2021)
[8] Hwang PH, Longstreth WT, Brenowitz WD, Thielke SM, Lopez OL, Francis CE, Et al., Dual sensory impairment in older adults and risk of dementia from the GEM Study, Alzheimers Dement (Amst), 12, (2020)
[9] Risacher SL, WuDunn D, Tallman EF, West JD, Gao S, Farlow MR, Et al., Visual contrast sensitivity is associated with the presence of cerebral amyloid and tau deposition, Brain Commun, 2, (2020)
[10] Blanks JC, Hinton DR, Sadun AA, Miller CA., Retinal ganglion cell degeneration in Alzheimer’s disease, Brain Res, 501, pp. 364-372, (1989)

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