Second Near-Infrared Window Fluorescence Materials for In Vivo Dynamic Multiplexed Imaging

被引：3

作者：

Fan, Fang ^{[1
]}

Zeng, Keyun ^{[1
,2
]}

Zhu, Yingying ^{[1
]}

Zhang, Yuxin ^{[1
]}

Chen, Yu ^{[1
]}

Lv, Diya ^{[1
]}

Jia, Dan ^{[1
]}

Chai, Yifeng ^{[1
]}

Chen, Xiaofei ^{[1
]}

Li, Quan ^{[3
,4
]}

机构：

[1] Sch Pharm, Shanghai 200433, Peoples R China

[2] Gen Hosp Western Theater Command, Dept Clin Pharm, Chengdu 610000, Peoples R China

[3] Southeast Univ, Inst Adv Mat, Nanjing 211189, Peoples R China

[4] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2025年

基金：

中国国家自然科学基金;

关键词：

multiplexed imaging; quantum dot; rare-earth nanoparticle; second near-infrared (NIR-II) window material; single-walled carbon nanotube; WALLED CARBON NANOTUBES; NIR-II NANOFLUOROPHORE; AG2SE QUANTUM DOTS; UP-CONVERSION; MOLECULAR RECOGNITION; NANOCRYSTALS; LUMINESCENCE; NANOPARTICLES; MULTICOLOR; EMISSION;

D O I：

10.1002/adfm.202422693

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Second near-infrared (NIR-II) fluorescence imaging has emerged as a breakthrough technology for accurately revealing complex mechanisms in vivo owing to its high sensitivity, deeper tissue penetration, high spatiotemporal resolution, and high throughput. This review provides a comprehensive overview of NIR-II fluorescence imaging, specifically focusing on the materials used, including single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth nanoparticles (RENPs), and organic fluorophores (OFs). It details their development, application, and advantageous performance in NIR-II fluorescence imaging. Furthermore, this review highlights an approach to dynamic multiplexed NIR-II fluorescence imaging in vivo that enables multitarget detection, providing a powerful tool for accurately and effectively assessing pathological processes and revealing complex biological mechanisms in vivo. Finally, it explores the aspects of translational medicine for NIR-II imaging, addressing challenges, and future prospects related to material development, detection equipment, and unmet biomedical applications.

引用

页数：29

共 193 条

[91] Design of NIR-II high performance organic small molecule fluorescent probes and summary of their biomedical applications [J].