Micro/nanorobots for gastrointestinal tract

被引:0
作者
Sui, Ziqi [1 ]
Wan, Chugen [2 ]
Cheng, Hefei [2 ]
Yang, Bin [3 ]
机构
[1] Zhejiang Chinese Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Hangzhou, Zhejiang, Peoples R China
[2] First Peoples Hosp Linping Dist, Dept Gastroenterol, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gastroenterol, Hangzhou, Zhejiang, Peoples R China
来源
FRONTIERS IN CHEMISTRY | 2024年 / 12卷
关键词
micro/nanomotors; gastrointestinal tract; targeted delivery; physiological barriers; applications; ORAL-DRUG DELIVERY; MICROMOTORS; MOTORS; NANOPARTICLES; FUNDAMENTALS; PENETRATION; MICROBIOTA; INFECTION; CARRIER; MOTION;
D O I
10.3389/fchem.2024.1423696
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The application of micro/nanomotors (MNMs) in the gastrointestinal tract has become a Frontier in the treatment of gastrointestinal diseases. These miniature robots can enter the gastrointestinal tract through oral administration, achieving precise drug delivery and therapy. They can traverse mucosal layers and tissue barriers, directly targeting tumors or other lesion sites, thereby enhancing the bioavailability and therapeutic effects of drugs. Through the application of nanotechnology, these MNMs are able to accomplish targeted medication release, regulating drug release in response to either external stimuli or the local biological milieu. This results in reduced side effects and increased therapeutic efficacy. This review summarizes the primary classifications and power sources of current MNMs, as well as their applications in the gastrointestinal tract, providing inspiration and direction for the treatment of gastrointestinal diseases with MNMs.
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页数:18
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共 116 条
  • [1] Micro- and nano-motors for biomedical applications
    Abdelmohsen, Loai K. E. A.
    Peng, Fei
    Tu, Yingfeng
    Wilson, Daniela A.
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (17) : 2395 - 2408
  • [2] Light-Driven Directed Motion of Azobenzene-Coated Polymer Nanoparticles in an Aqueous Medium
    Abid, Jean-Pierre
    Frigoli, Michel
    Pansu, Robert
    Szeftel, Jacob
    Zyss, Joseph
    Larpent, Chantal
    Brasselet, Sophie
    [J]. LANGMUIR, 2011, 27 (13) : 7967 - 7971
  • [3] Selectively manipulable acoustic-powered microswimmers
    Ahmed, Daniel
    Lu, Mengqian
    Nourhani, Amir
    Lammert, Paul E.
    Stratton, Zak
    Muddana, Hari S.
    Crespi, Vincent H.
    Huang, Tony Jun
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [4] High-Yield Production of Biohybrid Microalgae for On-Demand Cargo Delivery
    Akolpoglu, Mukrime Birgul
    Dogan, Nihal Olcay
    Bozuyuk, Ugur
    Ceylan, Hakan
    Kizilel, Seda
    Sitti, Metin
    [J]. ADVANCED SCIENCE, 2020, 7 (16)
  • [5] Advances in Oral Drug Delivery
    Alqahtani, Mohammed S.
    Kazi, Mohsin
    Alsenaidy, Mohammad A.
    Ahmad, Muhammad Z.
    [J]. FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [6] Nanocomposite systems for precise oral delivery of drugs and biologics
    Andretto, Valentina
    Rosso, Annalisa
    Briancon, Stephanie
    Lollo, Giovanna
    [J]. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2021, 11 (02) : 445 - 470
  • [7] The Lucky Iron Fish: a simple solution for iron deficiency
    Armstrong, Gavin R.
    [J]. BLOOD ADVANCES, 2017, 1 (05) : 330 - 330
  • [8] Recent Advances in Engineering the Stem Cell Microniche in 3D
    Bao, Min
    Xie, Jing
    Huck, Wilhelm T. S.
    [J]. ADVANCED SCIENCE, 2018, 5 (08):
  • [9] Fecal Microbiota Transplantation for Dysbiosis - Predictable Risks
    Blaser, Martin J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (21) : 2064 - 2066
  • [10] Mucus as a Barrier to Drug Delivery - Understanding and Mimicking the Barrier Properties
    Boegh, Marie
    Nielsen, Hanne Morck
    [J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2015, 116 (03) : 179 - 186