Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia

被引：0
|
作者：
Canichella, Martina [1 ]
Molica, Matteo [2 ]
Mazzone, Carla [1 ]
de Fabritiis, Paolo [1 ,3 ]
机构：
[1] ASL Roma2, St Eugenio Hosp, Hematol, I-00144 Rome, Italy
[2] Azienda Osped Pugliese Ciaccio, Dept Hematol Oncol, I-88100 Catanzaro, Italy
[3] Tor Vergata Univ, Dept Biomed & Prevenz, I-00133 Rome, Italy
来源：
CURRENT ONCOLOGY | 2024年 / 31卷 / 10期
关键词：
acute myeloid leukemia (AML); hematopoietic stem cell transplantation (HSCT); maintenance therapy post-HSCT in AML; targeted drugs; cellular therapy; hypometylating agents; DONOR LYMPHOCYTE INFUSION; REGULATORY T-CELLS; MYELODYSPLASTIC SYNDROMES; AZACITIDINE; AML; RELAPSE; MUTATIONS; MDS; CHEMOTHERAPY; MALIGNANCIES;
D O I：
10.3390/curroncol31100451
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High-risk acute myeloid leukemia has been associated with a poor outcome. Hematopoietic stem cell transplantation (HSCT) represents the only curative option for eligible patients. Relapse after HSCT is a dramatic event with poor chances of survival. With the aim of reducing the rate of post-HSCT relapse, maintenance treatment has been investigated in this setting. Results from clinical trials suggest an advantage in the use of a maintenance strategy; however, standardized guidelines are not yet available due to the lack of prospective clinical trials. In this review, we have reported the most important strategies adopted as post-HSCT maintenance, highlighting their efficacy, but the current research also opens questions.
引用
收藏
页码：6050 / 6060
页数：11
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