VALPROIC ACID AND PLASMA-LEVELS OF PHENYTOIN

被引:34
作者
BRUNI, J
WILDER, BJ
WILLMORE, LJ
BARBOUR, B
机构
[1] VET ADM HOSP, MED CTR, NEUROL SERV 127, GAINESVILLE, FL 32602 USA
[2] UNIV FLORIDA, COLL MED, DEPT NEUROL, GAINESVILLE, FL 32611 USA
关键词
D O I
10.1212/WNL.29.6.904
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Seizure patients (8) were treated concurrently with a constant dose of the anticonvulsants phenytoin and valproic acid for 1 yr. During initial therapy with valproic acid total plasma phenytoin levels decreased. The interaction was transient and was not seen at the end of 1 yr. Total plasma phenytoin levels returned to pre-valproic-acid levels in 7 patients.
引用
收藏
页码:904 / 905
页数:2
相关论文
共 13 条
[1]   SODIUM VALPROATE IN TREATMENT OF INTRACTABLE SEIZURE DISORDERS - CLINICAL AND ELECTROENCEPHALOGRAPHIC STUDY [J].
ADAMS, DJ ;
LUDERS, H ;
PIPPENGER, C .
NEUROLOGY, 1978, 28 (02) :152-157
[2]  
BARDY A, 1976, LANCET, V2, P1297
[3]   SODIUM VALPROATE IN TREATMENT OF RESISTANT EPILEPSY [J].
HASSAN, MN ;
LALJEE, HCK ;
PARSONAGE, MJ .
ACTA NEUROLOGICA SCANDINAVICA, 1976, 54 (03) :209-218
[4]   SODIUM VALPROATE IN TREATMENT OF EPILEPSY [J].
JEAVONS, PM ;
CLARK, JE .
BRITISH MEDICAL JOURNAL, 1974, 2 (5919) :584-586
[5]  
JORDAN BJ, 1975, CLIN PHARMACOLOGICAL, P112
[6]   VALPROIC ACID IN EPILEPSY - CLINICAL AND PHARMACOLOGICAL EFFECTS [J].
MATTSON, RH ;
CRAMER, JA ;
WILLIAMSON, PD ;
NOVELLY, RA .
ANNALS OF NEUROLOGY, 1978, 3 (01) :20-25
[7]  
PATSALOS PN, 1977, LANCET, V1, P50
[8]   EFFECT OF SODIUM VALPROATE ON PLASMA-PROTEIN BINDING OF DIPHENYLHYDANTOIN [J].
PATSALOS, PN ;
LASCELLES, PT .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1977, 40 (06) :570-574
[9]   CONTROLLED TRIAL OF SODIUM VALPROATE IN SEVERE EPILEPSY [J].
RICHENS, A ;
AHMAD, S .
BRITISH MEDICAL JOURNAL, 1975, 4 (5991) :255-256
[10]  
VAJDA F, 1975, CLIN PHARMACOLOGICAL, P92