Threading the Needle: Navigating Novel Immunotherapeutics in Pancreatic Ductal Adenocarcinoma

被引：0

作者：

Demir, Tarik ^{[1
]}

Moloney, Carolyn ^{[1
]}

Mahalingam, Devalingam ^{[1
]}

机构：

[1] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Dev Therapeut, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CANCERS | 2025年 / 17卷 / 05期

关键词：

biomarkers; immunology; immunotherapy; pancreas adenocarcinoma; resistance mechanisms; MISMATCH REPAIR DEFICIENCY; REGULATORY T-CELLS; HLA-DR EXPRESSION; TUMOR DNA CTDNA; IFN-GAMMA; SOLID TUMORS; PHASE-I; MONOCLONAL-ANTIBODY; PEPTIDE VACCINATION; PARP INHIBITION;

D O I：

10.3390/cancers17050715

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with a poor prognosis. Currently, chemotherapy is the only option for most patients with advanced-stage PDAC. Further, conventional immunotherapies and targeted therapies improve survival outcomes only in rare PDAC patient subgroups. To date, combinatory immunotherapeutic strategies to overcome the immune-hostile PDAC tumor microenvironment (TME) have resulted in limited efficacy in clinical studies. However, efforts are ongoing to develop new treatment strategies for patients with PDAC with the evolving knowledge of the TME, molecular characterization, and immune resistance mechanisms. Further, the growing arsenal of various immunotherapeutic agents, including novel classes of immune checkpoint inhibitors and oncolytic, chimeric antigen receptor T cell, and vaccine therapies, reinforces these efforts. This review will focus on the place of immunotherapy and future possible strategies in PDAC.

引用

页数：42

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