Glutathione-responsive Aggregation-induced Emission Photosensitizers for Enhanced Photodynamic Therapy of Lung Cancer

被引：0

作者：

Sun, Feiyi ^{[1
]}

Chen, Yuyang ^{[1
,2
]}

Lam, Kristy W. K. ^{[1
]}

Du, Wutong ^{[1
]}

Liu, Qingqing ^{[3
]}

Han, Fei ^{[2
]}

Li, Dan ^{[2
]}

Lam, Jacky W. Y. ^{[1
]}

Sun, Jianwei ^{[1
]}

Kwok, Ryan T. K. ^{[1
]}

Tang, Ben Zhong ^{[1
,4
]}

机构：

[1] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Hong Kong Branch, Dept Chem,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China

[2] Shenzhen Bay Lab, Inst Infect Dis, Shenzhen 518132, Peoples R China

[3] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Pokfulam, Hong Kong 999077, Peoples R China

[4] Chinese Univ Hong Kong Shenzhen CUHK Shenzhen, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China

来源：

SMALL | 2024年 / 20卷 / 40期

基金：

中国国家自然科学基金;

关键词：

aggregation-induced emissions; glutathione; intersystem crossing; lung cancer; photodynamic therapy; FLUORESCENCE; MECHANISMS; ROS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lung cancer, a highly prevalent and lethal form of cancer, is often associated with oxidative stress. Photodynamic therapy (PDT) has emerged as a promising alternative therapeutic tool in cancer treatments, but its efficacy is closely correlated to the photosensitizers generating reactive oxygen species (ROS) and the antioxidant capacity of tumor cells. In particular, glutathione (GSH) can reduce the ROS and thus compromise PDT efficacy. In this study, a GSH-responsive near-infrared photosensitizer (TBPPN) based on aggregation-induced emission for real-time monitoring of GSH levels and enhanced PDT for lung cancer treatment is developed. The strategic design of TBPPN, consisting of a donor-acceptor structure and incorporation of dinitrobenzene, enables dual functionality by not only the fluorescence being activated by GSH but also depleting GSH to enhance the cytotoxic effect of PDT. TBPPN demonstrates synergistic PDT efficacy in vitro against A549 lung cancer cells by specifically targeting different cellular compartments and depleting intracellular GSH. In vivo studies further confirm that TBPPN can effectively inhibit tumor growth in a mouse model with lung cancer, highlighting its potential as an integrated agent for the diagnosis and treatment of lung cancer. This approach enhances the effectiveness of PDT for lung cancer and deserves further exploration of its potential for clinical application.

引用

页数：12