Neuroprotective effects of magnesium: implications for neuroinflammation and cognitive decline

被引：3
作者：
Patel, Veer [1 ]
Akimbekov, Nuraly S. [2 ,3 ]
Grant, William B. [4 ]
Dean, Carolyn [5 ]
Fang, Xiaoqian [6 ]
Razzaque, Mohammed S. [1 ,7 ]
机构：
[1] Lake Erie Coll Osteopath Med, Dept Pathol, Erie, PA 16509 USA
[2] West Kazakhstan Marat Ospanov Med Univ, Sci Pract Ctr, Aktobe, Kazakhstan
[3] Al Farabi Kazakh Natl Univ, Sustainabil Ecol & Bioresources, Alma Ata, Kazakhstan
[4] Sunlight Nutr & Hlth Res Ctr, San Francisco, CA USA
[5] New Capstone Inc, Mooresville, NC USA
[6] Univ Texas Rio Grande Valley UTRGV, Sch Med, Dept Neurosci, Edinburg, TX USA
[7] Univ Texas Rio Grande Valley UTRGV, Sch Med, Dept Med Educ, Edinburg, TX 78541 USA
来源：
FRONTIERS IN ENDOCRINOLOGY | 2024年 / 15卷
关键词：
magnesium; neuroinflammation; neurodegenerative disease; cognitive decline; neuroprotection; SUPPLEMENTATION; PLASTICITY; DEMENTIA; SULFATE; DISEASE; MEMORY; MODEL;
D O I：
10.3389/fendo.2024.1406455
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neurodegenerative diseases, which are characterized by progressive neuronal loss and cognitive decline, are a significant concern for the aging population. Neuroinflammation, a shared characteristic of these diseases, is implicated in their pathogenesis. This article briefly summarizes the role of magnesium, an essential mineral involved in numerous enzymatic reactions and critical for neuronal bioactivity, in the context of neuroinflammation and cognitive decline. The potential neuroprotective effects of magnesium, including the mechanisms of neuroprotection by magnesium through maintaining neuronal ion homeostasis, reducing inflammation, and preventing excitotoxicity, are also described. Additionally, we discuss the impact of inadequate magnesium on neuroinflammation and its potential as a therapeutic agent for attenuating cognitive decline to improve neurodegenerative conditions.
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页数：8
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