NAFLD vs MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)-Why the Need for a Change of Nomenclature?

被引：0

作者：

Gastaldelli, Amalia ^{[1
]}

Newsome, Philip N. ^{[2
,3
]}

机构：

[1] Natl Res Council CNR, Inst Clin Physiol IFC, Cardiometab Risk Lab, I-56124 Pisa, Italy

[2] Kings Coll London, Roger Williams Inst Liver Studies, Fac Life Sci & Med, Sch Immunol & Microbial Sci,Fdn Liver Res, London SE5 9NT, England

[3] Kings Coll Hosp London, London SE5 9NT, England

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2025年 / 110卷 / 07期

关键词：

MASLD; MASH; fibrosis; insulin resistance; free fatty acids; glucagon like peptide 1 receptor agonists; NONALCOHOLIC FATTY LIVER; STEATOHEPATITIS; MANAGEMENT; RISK;

D O I：

10.1210/clinem/dgaf094

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several reasons led to the change in the nomenclature from nonalcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated steatotic liver disease (MASLD); the most important being limitations due to the reliance on exclusionary confounder terms and the use of potentially stigmatizing language (the terms "nonalcoholic" and "fatty"). The new name was decided through a Delphi process and now includes in the name, and definition, the metabolic origin (the presence of at least 1 of 5 cardiometabolic risk factors) without the stigmatizing terms. The recognition of a new category termed "metabolic and alcohol related/associated liver disease" (MetALD) opens up a new area for exploration although the relative contribution of alcohol and metabolic risk factors requires further evaluation as does the evidencing at a patient rather than population level.

引用

页码：e2407 / e2410

页数：4

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