Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery

被引：3
作者：
Trinh, Quynh Dieu [1 ]
Mai, Huynh Nhu [3 ]
Pham, Duc Toan [2 ]
机构：
[1] Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City, Vietnam
[2] Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City, Vietnam
[3] Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City, Vietnam
来源：
REGENERATIVE THERAPY | 2024年 / 26卷
关键词：
12; September; 2024; Neurodegenerative diseases; Stem cell therapy; Mesenchymal stem cells; Circadian rhythm; Antibody drugs; Neuroinflammation; MOUSE MODEL; STROMAL CELLS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; PASSIVE-IMMUNIZATION; CIRCADIAN-RHYTHMS; BRAIN-DAMAGE; A-BETA; MECHANISMS; NEUROINFLAMMATION;
D O I：
10.1016/j.reth.2024.09.014
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Neurodegenerative diseases are central or peripheral nervous system disorders associated with progressive brain cell degeneration. Common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis have been widely studied. However, current therapeutics only reduce the symptoms and do not ameliorate the pathogenesis of these diseases. Recent studies suggested the roles of neuroinflammation, apoptosis, and oxidative stress in neurodegenerative diseases. Mesenchymal stem cells (MSCs) exert anti-apoptotic, anti-inflammatory, and antioxidative effects. Therefore, investigating the effects of MSCs and their applications may lead to the discovery of more effective therapies for neurodegenerative diseases. In this study, we review different approaches used to identify therapies for neurodegenerative diseases using MSCs. (c) 2024 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
引用
收藏
页码：981 / 989
页数：9
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