The Compelling Role of Brain-Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators

被引：9

作者：

Al-kuraishy, Hayder M. ^{[1
]}

Sulaiman, Ghassan M. ^{[2
]}

Mohammed, Hamdoon A. ^{[3
]}

Albukhaty, Salim ^{[4
]}

Albuhadily, Ali K. ^{[1
]}

Al-Gareeb, Ali I. ^{[5
]}

Klionsky, Daniel J. ^{[6
]}

Abomughaid, Mosleh M. ^{[7
]}

机构：

[1] Mustansiriyah Univ, Coll Med, Dept Clin Pharmacol & Med, Baghdad, Iraq

[2] Univ Technol Baghdad, Dept Appl Sci, Div Biotechnol, Baghdad, Iraq

[3] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Qasim, Saudi Arabia

[4] Al Manara Coll Med Sci, Amarah, Maysan, Iraq

[5] Jabir Ibn Hayyan Med Univ, Najaf, Iraq

[6] Univ Michigan, Life Sci Inst, Ann Arbor, MI USA

[7] Univ Bisha, Coll Appl Med Sci, Dept Med Lab Sci, Bisha, Saudi Arabia

来源：

CNS NEUROSCIENCE & THERAPEUTICS | 2024年 / 30卷 / 12期

关键词：

brain-derived neurotrophic factor; multiple sclerosis; neuromodulator; pathogenesis; tropomyosin receptor kinase B; BLOOD MONONUCLEAR-CELLS; GLATIRAMER ACETATE; INTERFERON-BETA; KETOGENIC DIETS; IFN-BETA; EXERCISE; RECEPTOR; EXPRESSION; IMMUNE; SERUM;

D O I：

10.1111/cns.70167

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is a neurotrophin, acting as a neurotrophic signal and neuromodulator in the central nervous system (CNS). BDNF is synthesized from its precursor proBDNF within the CNS and peripheral tissues. Through activation of NTRK2/TRKB (neurotrophic receptor tyrosine kinase 2), BDNF promotes neuronal survival, synaptic plasticity, and neuronal growth, whereas it inhibits microglial activation and the release of pro-inflammatory cytokines. BDNF is dysregulated in different neurodegenerative diseases and depressions. However, there is a major controversy concerning BDNF levels in the different stages of multiple sclerosis (MS). Therefore, this review discusses the potential role of BDNF signaling in stages of MS, and how BDNF modulators affect the pathogenesis and outcomes of this disease.

引用

页数：15

共 155 条

[1] Interferon-Gamma and Interleukin-1Beta Enhance the Secretion of Brain-Derived Neurotrophic Factor and Promotes the Survival of Cortical Neurons in Brain Injury [J].

Abd-El-Basset, Ebtesam M. ;

Rao, Muddanna Sakkattu ;

Alsaqobi, Ameerah .

NEUROSCIENCE INSIGHTS, 2020, 15

[2] Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice [J].

Acuna-Catalan, Diego ;

Shah, Samah ;

Wehrfritz, Cameron ;

Nomura, Mitsunori ;

Acevedo, Alejandro ;

Olmos, Cristina ;

Quiroz, Gabriel ;

Huerta, Hernan ;

Bons, Joanna ;

Ampuero, Estibaliz ;

Wyneken, Ursula ;

Sanhueza, Magdalena ;

Arancibia, Felipe ;

Contreras, Darwin ;

Cardenas, Julio Cesar ;

Morales, Bernardo ;

Schilling, Birgit ;

Newman, John C. ;

Gonzalez-Billault, Christian .

CELL REPORTS MEDICINE, 2024, 5 (06)

[3] Myelin Basic Protein in Oligodendrocyte-Derived Extracellular Vesicles as a Diagnostic and Prognostic Biomarker in Multiple Sclerosis: A Pilot Study [J].

Agliardi, Cristina ;

Guerini, Franca Rosa ;

Zanzottera, Milena ;

Bolognesi, Elisabetta ;

Picciolini, Silvia ;

Caputo, Domenico ;

Rovaris, Marco ;

Pasanisi, Maria Barbara ;

Clerici, Mario .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)

[4] Differential effect of metformin and/or glyburide on apelin serum levels in patients with type 2 diabetes mellitus: Concepts and clinical practice [J].

Al-Kuraishy, Havder M. ;

Al-Gareeb, Ali I. ;

Waheed, Huda J. ;

Al-Maiahy, Thabat J. .

JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH, 2018, 9 (03) :80-86

[5] Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle [J].

Al-kuraishy, Hayder M. ;

Jabir, Majid S. ;

Albuhadily, Ali K. ;

Al-Gareeb, Ali I. ;

Jawad, Sabrean F. ;

Swelum, Ayman A. ;

Hadi, Najah R. .

AGEING RESEARCH REVIEWS, 2024, 95

[6] Defective autophagy and autophagy activators in myasthenia gravis: a rare entity and unusual scenario [J].

Al-Kuraishy, Hayder M. ;

Sulaiman, Ghassan M. ;

Jabir, Majid S. ;

Mohammed, Hamdoon A. ;

Al-Gareeb, Ali I. ;

Albukhaty, Salim ;

Klionsky, Daniel J. ;

Abomughaid, Mosleh M. .

AUTOPHAGY, 2024, 20 (07) :1473-1482

[7] Sildenafil and depression: True or false prophecy [J].

Al-Kuraishy, Hayder M. ;

Alsaidan, Aseel Awad ;

Al-Gareeb, Ali I. ;

Alexiou, Athanasios ;

Papadakis, Marios ;

Batiha, Gaber El-Saber .

CNS NEUROSCIENCE & THERAPEUTICS, 2023, 29 (10) :3108-3109

[8] Balancing neurotrophin pathway and sortilin function: Its role in human disease [J].

Al-Yozbaki, Minnatallah ;

Acha-Sagredo, Amelia ;

George, Alex ;

Liloglou, Triantafillos ;

Wilson, Cornelia M. .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2020, 1874 (02)

[9] The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson's Disease: The Way of New Inroads [J].

Ali, Naif H. ;

Al-kuraishy, Hayder M. ;

Al-Gareeb, Ali I. ;

Alnaaim, Saud A. ;

Saad, Hebatallah M. ;

Batiha, Gaber El-Saber .

MOLECULAR NEUROBIOLOGY, 2024, 61 (05) :2469-2480

[10] Metformin role in Parkinson's disease: a double-sword effect [J].

Alrouji, Mohamed ;

Al-kuraishy, Hayder M. ;

Al-Gareeb, Ali I. ;

Ashour, Nada A. ;

Jabir, Majid S. ;

Negm, Walaa A. ;

Batiha, Gaber El-Saber .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2024, 479 (04) :975-991

← 1 2 3 4 5 6 7 8 9 10 →