Application of Peptide-Conjugated Photosensitizers for Photodynamic Cancer Therapy: A Review

被引：0
作者：
Vale, Nuno [1 ,2 ,3 ]
Ramos, Raquel [1 ,2 ,3 ]
Cruz, Ines [1 ,2 ]
Pereira, Mariana [1 ,2 ,4 ]
机构：
[1] Ctr Hlth Technol & Serv Res CINTESIS, PerMed Res Grp, Rua Doutor Placido da Costa, P-4200450 Porto, Portugal
[2] Univ Porto, Fac Med, CINTESIS RISE, Alameda Hernani Monteiro, P-4200319 Porto, Portugal
[3] Univ Porto, Fac Med, Dept Community Med Hlth Informat & Decis MEDCIDS, Rua Doutor Placido da Costa, P-4200450 Porto, Portugal
[4] Univ Porto, ICBAS Sch Med & Biomed Sci, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal
来源：
ORGANICS | 2024年 / 5卷 / 04期
关键词：
cancer; photodynamic therapy; photosensitizers; reactive oxygen species; peptides; CELL-PENETRATING PEPTIDES; DRUG-DELIVERY; PYROPHEOPHORBIDE-A; TAT; LIPOSOMES; MECHANISMS; EFFICACY; ACCUMULATION; DOXORUBICIN; TRANSPORTAN;
D O I：
10.3390/org5040022
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Photodynamic therapy (PDT) is a clinically approved therapeutic option for the treatment of various types of cancer. PDT calls for the application of photosensitizers (PSs) and photoactivation with a particular light wavelength while tissue oxygen is present. Anticancer efficacy depends on the combination of these three substrates leading to the generation of cytotoxic reactive oxygen species (ROS) that promote apoptosis, necrosis, and autophagy of cancer cells. However, one of the biggest problems with conventional PDT is the poor accumulation and targeting of PSs to tumor tissues, resulting in undesirable side effects and unfavorable therapeutic outcomes. To overcome this, new photosensitizers have been developed through bioconjugation and encapsulation with targeting molecules, such as peptides, allowing a better accumulation and targeting in tumor cells. Several studies have been conducted to test the efficacy of several peptide-conjugated photosensitizers and improve PDT efficacy. This review aims to present current insights into various types of peptide-conjugated photosensitizers, with the goal of enhancing cancer treatment efficacy, addressing the limitations of conventional PDT, and expanding potential applications in medicine.
引用
收藏
页码：429 / 442
页数：14
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