HNF1A-AS1 promotes oral squamous cell carcinoma progression via regulating miR-138/CDK6 pathway

被引：0
作者：
Mei, Bingxin [1 ]
Zeng, Zhimei [1 ]
Xia, Qinmin [1 ]
Liu, Ming [1 ]
Lei, Li [1 ]
机构：
[1] Gannan Med Univ, Dept Stomatol, Affiliated Hosp 1, 128 Jinling Rd, Ganzhou 341000, Jiangxi, Peoples R China
来源：
ODONTOLOGY | 2025年 / 113卷 / 03期
关键词：
HNF1A-AS1; miR-138; CDK6; Progression; OSCC; UP-REGULATION; RESISTANCE;
D O I：
10.1007/s10266-025-01057-w
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The action and the latent mechanism of HNF1A-AS1 in oral squamous cell carcinoma (OSCC) development were probed. Levels of HNF1A-AS1, microRNA-138 (miR-138) and Cyclin-dependent kinase 6 (CDK6) were examined. In vitro assays were conducted using SCC-4 and SCC15 cells derived from a human SCC of the tongue of a 55-year-old male. In vivo assay was performed by establishing OSCC mouse models. An elevated HNF1A-AS1 was detected in OSCC, and down-expressed HNF1A-AS1 inhibited migration and invasion, and promoted apoptosis in OSCC cells in vitro. HNF1A-AS1 targeted miR-138 to positively regulate the expression of CDK6, a target of miR-138. Knockdown of miR-138 attenuated the action of HNF1A-AS1 silencing on OSCC cell malignant phenotypes. Besides that, overexpression of CDK6 weakened miR-138-mediated anti-cancer functions. Moreover, HNF1A-AS1 knockdown restrained OSCC growth in nude mice. HNF1A-AS1 promoted OSCC tumorigenesis via miR-138/CDK6 pathway, indicating the potential molecular contribution of HNF1A-AS1 on OSCC pathogenesis.
引用
收藏
页码：1137 / 1147
页数：11
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