Risk of stroke in Alzheimer's disease: A meta-analysis

被引:0
作者
Liu, Juan [1 ]
Wang, Xiaome ng [1 ]
Ru, Yanni [1 ]
Yang, Na [1 ]
Zhang, Yufeng [1 ]
Zhang, Bei [1 ]
机构
[1] Xian Med Univ, Dept Neurol, Affiliated Hosp 1, Xian 710077, Peoples R China
关键词
Alzheimer's disease; stroke; age; DALY; ischemic stroke; hemorrhagic stroke;
D O I
10.54029/2024jkp
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Stroke occurs when a blood vessel of the brain narrowed or completely blocked. Stroke and Alzheimer's disease (AD) are the commonest diseases in elderly. Some studies confirm the association between AD and the increased risk of stroke. Methods: In present meta-analysis we conducted a systematic analysis on risk of stroke in AD patients. A thorough literature search was conducted using different databases, including Google Scholar and MEDLINE. The present metanalysis includes all the studies published from 2010 to 2023. We found more than 57,260 matching results and five were relevant to our area of interest and met all the selection criteria. Results: All the selected studies confirm the association of stroke with AD. The AD patients were al higher risk of stroke (ischemic and haemorrhagic) than the normal individuals. Conclusion: Present meta-analysis confirms the significant association of AD with stroke. There were only five studies available. To validate the results further evidences are required.
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收藏
页码:553 / 558
页数:6
相关论文
共 18 条
  • [1] Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019, Lancet, 396, 10258, pp. 1204-1222, (2020)
  • [2] Global Stroke Factsheet, Int J Stroke, 17, 1, pp. 18-29, (2022)
  • [3] Reitz C., Bos M.J., Hofman A., Koudstaal P.J., Breteler M., Prestroke cognitive performance, incident stroke, and risk of dementia: The Rotterdam Study, Stroke, 39, pp. 36-41, (2008)
  • [4] Feigin V.L., Krishnamurthi R.V., Parmar P., Et al., Update on the global burden of ischemic and hemorrhagic stroke in 1990-2013: The GBD 2013 study, Neuroepidemiology, 45, (2015)
  • [5] Mergenthaler P., Dirnagl U., Meisel A., Pathophysiology of stroke: Lessons from animal models, Metab Brain Dis, 19, pp. 151-167, (2004)
  • [6] Kumarasamy C., Tiwary V., Sunil K., Et al., Prognostic utility of platelet–lymphocyte ratio, neutrophil– lymphocyte ratio and monocyte–lymphocyte ratio in head and neck cancers: A detailed PRISMA compliant systematic review and meta-analysis, Cancers, 13, 16, (2021)
  • [7] Chi N.F., Chien L.N., Ku H.L., Hu C.J., Chiou H.Y., Alzheimer disease and risk of stroke: A population-based cohort study, Neurology, 80, 8, pp. 705-711, (2013)
  • [8] Cook M., Baker N., Lanes S., Bullock R., Wentworth C., Arrighi H.M., Incidence of stroke and seizure in Alzheimer’s disease dementia, Age Ageing, 44, 4, pp. 695-699, (2015)
  • [9] Tolppanen A.M., Lavikainen P., Solomon A., Kivipelto M., Soininen H., Hartikainen S., Incidence of stroke in people with Alzheimer disease: A national register– based approach, Neurology, 80, 4, pp. 353-358, (2013)
  • [10] Taipale H., Koponen M., Tanskanen A., Et al., Use of benzodiazepines and related drugs is associated with a risk of stroke among persons with Alzheimer’s disease, Int Clin Psychopharmacol, 32, 3, pp. 135-144, (2017)