Catheter-related thrombosis in adults with cancer: a secondary analysis of a prospective randomized controlled trial

被引：0

作者：

Hapgood, Greg ^{[1
,2
]}

Hill, Kate ^{[1
,2
]}

Okano, Satomi ^{[3
]}

Abro, Emad ^{[2
]}

Looke, David ^{[1
,4
]}

Kennedy, Glen ^{[1
,5
]}

Pavilion, Gilbert ^{[6
]}

Van Kuilenburg, Rosita ^{[2
]}

Geary, Alanna ^{[7
]}

Joubert, Warren ^{[8
]}

Eastgate, Melissa ^{[7
]}

Jones, Mark ^{[9
]}

Mollee, Peter ^{[1
,2
]}

机构：

[1] Univ Queensland, Sch Med, Brisbane, Australia

[2] Princess Alexandra Hosp, Div Canc Serv, Brisbane, Australia

[3] QIMR Berghofer Med Res Inst, Stat Unit, Herston, Australia

[4] Princess Alexandra Hosp, Dept Infect Dis, Brisbane, Australia

[5] Royal Brisbane & Womens Hosp, Dept Haematol, Brisbane, Australia

[6] PRINCESS ALEXANDRA HOSP, Dept Intervent Radiol, BRISBANE, Australia

[7] Royal Brisbane & Womens Hosp, Canc Care Serv, Brisbane, Qld, Australia

[8] Greenslopes Private Hosp, Dept Oncol, Brisbane, Australia

[9] Univ Queensland, Sch Publ Hlth, Brisbane, Australia

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2025年 / 23卷 / 02期

基金：

英国医学研究理事会;

关键词：

cancer; central venous catheter; randomized controlled trial; thrombosis; INSERTED CENTRAL CATHETERS; RISK-FACTORS; HEMATOLOGICAL MALIGNANCIES;

D O I：

10.1016/j.jtha.2024.11.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Catheter-related thrombosis (CRT) is a complication of central venous access devices (CVADs). Evidence is variable regarding the significance of the side of catheter insertion. The role of the patient's hand dominance in predisposition to CRT remains uncertain. Objectives: In a prospective randomized controlled trial, adult cancer patients were randomly allocated to either dominant or nondominant side CVAD insertion. The primary endpoint of this trial examined the incidence of catheter-associated bloodstream infection. Here, we report the secondary endpoint of the incidence of CRT. Methods: Six hundred forty CVADs were randomized to the dominant (n = 322) or nondominant (n = 318) side of insertion. Only symptomatic patients underwent ultrasound imaging to evaluate for CRT. Results: The median patient age was 58 years, 60% of patients had hematologic malignancies and 40% had solid tumors. CVADs used were peripherally-inserted central catheter line (67%), tunneled CVAD (23%), or nontunneled CVAD (10%). The CRT incidence rate was 0.65 versus 0.82 per 1000 line days in the dominant versus nondominant group (hazard ratio [HR], 1.2; 95% CI, 0.58-2.48; P = .63). There was no significant difference in CRT incidence rate between left- and right-sided insertions (HR, 0.63; 95% CI, 0.30-1.32; P = .22). The CRT incidence rate was lower in right-handed versus left-handed line inserters (HR, 0.29; 95% CI, 0.12-0.71; P = .007). Conclusion: The rate of CRT was not associated with whether CVAD insertion was on the patient's dominant or nondominant side or the side of insertion. The role of inserter hand dominance requires further investigation.

引用

页码：627 / 634

页数：8

共 21 条

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