Smoking cessation and atherosclerotic cardiovascular events and mortality in chronic kidney disease

被引：0

作者：

Joo, Young Su ^{[1
,2
,3
]}

Yun, Hae-Ryoung ^{[1
,2
,3
]}

Kim, Hyung Woo ^{[1
,3
]}

Koh, Hee Byung ^{[1
,4
]}

Jung, Chan-Young ^{[1
,5
]}

Chang, Tae-Ik ^{[6
]}

Park, Jung Tak ^{[1
,3
]}

Park, Sue Kyung ^{[7
]}

Hyun, Young Youl ^{[8
]}

Kim, Yeong Hoon ^{[9
]}

Sung, Suah ^{[10
]}

Yoo, Tae-Hyun ^{[1
]}

Oh, Kook-Hwan ^{[11
]}

Kang, Shin-Wook ^{[1
]}

Han, Seung Hyeok ^{[1
]}

机构：

[1] Yonsei Univ, Inst Kidney Dis Res, Coll Med, Dept Internal Med, Seoul, South Korea

[2] Yonsei Univ, Yongin Severance Hosp, Dept Internal Med, Div Nephrol,Dept Internal Med, Yongin, South Korea

[3] Yonsei Univ, Inst Innovat Digital Healthcare, Seoul, South Korea

[4] Catholic Kwandong Univ, Int St Marys Hosp, Dept Internal Med, Incheon, South Korea

[5] Asan Med Ctr, Dept Internal Med, Div Nephrol, Seoul, South Korea

[6] Ilsan Hosp, Dept Internal Med, Natl Hlth Insurance Serv, Med Ctr, Goyang, South Korea

[7] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[8] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Internal Med, Seoul, South Korea

[9] Inje Univ, Busan Paik Hosp, Dept Internal Med, Busan, South Korea

[10] Eulji Univ, Eulji Med Ctr, Dept Internal Med, Seoul, South Korea

[11] Seoul Natl Univ Hosp, Kidney Res Inst, Dept Internal Med, Seoul, South Korea

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2025年

关键词：

atherosclerotic cardiovascular disease; chronic kidney disease; smoking cessation; CORONARY-HEART-DISEASE; ALL-CAUSE; RISK-FACTORS; ASSOCIATION; PROGRESSION; DEATH; CKD;

D O I：

10.1093/ndt/gfae268

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Background. Smoking cessation is recommended to reduce excess atherosclerotic cardiovascular disease (ASCVD) and mortality in patients with chronic kidney disease (CKD). However, this recommendation is largely based on observational studies on the general population Therefore, we aimed to evaluate the association of smoking dose and smoking cessation duration with ASCVD and mortality in patients with CKD. Methods. We compiled a comprehensive pooled dataset comprising 66 245 participants with CKD from the KNOW-CKD and the UK Biobank cohort. Additionally, we included 307 353 participants without CKD from the UK Biobank cohort. Participants were categorized according to smoking dose and duration of smoking cessation base on a questionnaire. The primary outcome was a composite of ASCVD events or all-cause mortality. Results. Over a median follow-up period of 13.2 years, 14 671 (22.1%) participants reached the primary outcome. In the pooled CKD cohort, compared to never smokers, and former and current smokers exhibited a 1.30- and 2.14-fold higher risk of the primary outcome, respectively. Among former smokers, the hazard ratios (HRs) (95% confidence intervals [CIs]) for smoking loads <20 and >= 20 pack-years were 1.05 (1.00-1.10) and 2.14 (2.05-2.25), respectively. The increased risk of the primary outcome was attenuated by longer smoking cessation. The HRs (95% CIs) for smoking cessation of <10 years, 10-20 years, and >= 20 years were 1.75 (1.65-1.86), 1.43 (1.34-1.52), and 1.11 (1.06-1.16), respectively, compared with never smokers. This association was also observed in individuals without CKD, but the risk was comparable between former smokers with smoking cessation >= 20 years and non-smokers, suggesting that a longer cessation is required in patients with CKD to offset the smoking-related adverse effects. Conclusions. Among former smokers with CKD, the risk of ASCVD or mortality was substantially attenuated with less smoking load and a longer duration of smoking cessation.

引用

页数：10

共 43 条

[1] KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease Abstracts [J].

不详 .

KIDNEY INTERNATIONAL, 2021, 99 (03) :S26-S87

[2]

Benjamin EJ., 2018, CIRCULATION, V137, pe67, DOI DOI 10.1161/CIR.0000000000000573

[3] Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 [J].

Bikbov, Boris ;

Purcell, Carrie ;

Levey, Andrew S. ;

Smith, Mari ;

Abdoli, Amir ;

Abebe, Molla ;

Adebayo, Oladimeji M. ;

Afarideh, Mohsen ;

Agarwal, Sanjay Kumar ;

Agudelo-Botero, Marcela ;

Ahmadian, Elham ;

Al-Aly, Ziyad ;

Alipour, Vahid ;

Almasi-Hashiani, Amir ;

Al-Raddadi, Rajaa M. ;

Alvis-Guzman, Nelson ;

Amini, Saeed ;

Andrei, Tudorel ;

Andrei, Catalina Liliana ;

Andualem, Zewudu ;

Anjomshoa, Mina ;

Arabloo, Jalal ;

Ashagre, Alebachew Fasil ;

Asmelash, Daniel ;

Ataro, Zerihun ;

Atout, Maha Moh'd Wahbi ;

Ayanore, Martin Amogre ;

Badawi, Alaa ;

Bakhtiari, Ahad ;

Ballew, Shoshana H. ;

Balouchi, Abbas ;

Banach, Maciej ;

Barquera, Simon ;

Basu, Sanjay ;

Bayih, Mulat Tirfie ;

Bedi, Neeraj ;

Bello, Aminu K. ;

Bensenor, Isabela M. ;

Bijani, Ali ;

Boloor, Archith ;

Borzi, Antonio M. ;

Camera, Luis Alberto ;

Carrero, Juan J. ;

Carvalho, Felix ;

Castro, Franz ;

Catala-Lopez, Ferran ;

Chang, Alex R. ;

Chin, Ken Lee ;

Chung, Sheng-Chia ;

Cirillo, Massimo .

LANCET, 2020, 395 (10225) :709-733

[4] Self-Reported Tobacco, Alcohol, and Illicit Drug Use and Progression of Chronic Kidney Disease [J].

Bundy, Joshua D. ;

Bazzano, Lydia A. ;

Xie, Dawei ;

Cohan, Janet ;

Dolata, Jacqueline ;

Fink, Jeffrey C. ;

Hsu, Chi-yuan ;

Jamerson, Kenneth ;

Lash, James ;

Makos, Gail ;

Steigerwalt, Susan ;

Wang, Xue ;

Mills, Katherine T. ;

Chen, Jing ;

He, Jiang .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2018, 13 (07) :993-1001

[5] The UK Biobank resource with deep phenotyping and genomic data [J].

Bycroft, Clare ;

Freeman, Colin ;

Petkova, Desislava ;

Band, Gavin ;

Elliott, Lloyd T. ;

Sharp, Kevin ;

Motyer, Allan ;

Vukcevic, Damjan ;

Delaneau, Olivier ;

O'Connell, Jared ;

Cortes, Adrian ;

Welsh, Samantha ;

Young, Alan ;

Effingham, Mark ;

McVean, Gil ;

Leslie, Stephen ;

Allen, Naomi ;

Donnelly, Peter ;

Marchini, Jonathan .

NATURE, 2018, 562 (7726) :203-+

[6] Estimation of ten-year risk of fatal cardiovascular disease in Europe:: the SCORE project [J].

Conroy, RM ;

Pyörälä, K ;

Fitzgerald, AP ;

Sans, S ;

Menotti, A ;

De Backer, G ;

De Bacquer, D ;

Ducimetière, P ;

Jousilahti, P ;

Keil, U ;

Njolstad, I ;

Oganov, RG ;

Thomsen, T ;

Tunstall-Pedoe, H ;

Tverdal, A ;

Wedel, H ;

Whincup, P ;

Wilhelmsen, L ;

Graham, IM .

EUROPEAN HEART JOURNAL, 2003, 24 (11) :987-1003

[7]

COOK DG, 1986, LANCET, V2, P1376

[8] KDIGO 2022 CLINICAL PRACTICE GUIDELINE FOR DIABETES MANAGEMENT IN CHRONIC KIDNEY DISEASE [J].

de Boer, Ian H. ;

Rossing, Peter ;

Caramori, M. Luiza ;

Chan, Juliana C. N. ;

Heerspink, Hiddo J. L. ;

Hurst, Clint ;

Khunti, Kamlesh ;

Liew, Adrian ;

Michos, Erin D. ;

Navaneethan, Sankar D. ;

Olowu, Wasiu A. ;

Sadusky, Tami ;

Tandon, Nikhil ;

Tuttle, Katherine R. ;

Wanner, Christoph ;

Wilkens, Katy G. ;

Zoungas, Sophia ;

Jadoul, Michel ;

Winkelmayer, Wolfgang C. ;

Tonelli, Marcello A. ;

Craig, Jonathan C. ;

Strippoli, Giovanni F. M. ;

Tunnicliffe, David J. ;

Higgins, Gail Y. ;

Natale, Patrizia ;

Cooper, Tess E. ;

Willis, Narelle S. .

KIDNEY INTERNATIONAL, 2022, 102 (05) :S1-S127

[9]

Duncan MS, 2022, JAMA CARDIOL, V7, P195, DOI 10.1001/jamacardio.2021.4990

[10] Association of Smoking Cessation With Subsequent Risk of Cardiovascular Disease [J].

Duncan, Meredith S. ;

Freiberg, Matthew S. ;

Greevy, Robert A., Jr. ;

Kundu, Suman ;

Vasan, Ramachandran S. ;

Tindle, Hilary A. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 322 (07) :642-650

← 1 2 3 4 5 →