Nickel-Catalyzed Enantioselective Reductive Spirocyclization of 1,6-Enynes with o -Bromobenzaldehydes

被引：1

作者：

Guo, Haoyun ^{[1
]}

Chen, Yate ^{[2
]}

Kong, Wangqing ^{[1
]}

机构：

[1] Wuhan Univ, Inst Adv Studies IAS, Wuhan 430072, Peoples R China

[2] Huazhong Agr Univ, Coll Chem, Wuhan 430070, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2025年 / 57卷 / 08期

基金：

中国国家自然科学基金;

关键词：

nickel catalysis; enantioselectivity; reductive spirocyclization; 1,6-enynes; spiroindanones; COUPLING REACTIONS; SPIRO COMPOUNDS; CYCLIZATION; HALIDES; NOMENCLATURE;

D O I：

10.1055/a-2456-9530

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed a Ni-catalyzed asymmetric reductive spirocyclization of 1,6-enynes with o-haloaryl aldehydes. This approach provides an efficient method for the construction of chiral spiroindanone pyrrolidine derivatives in good yields with excellent enantio- and diastereoselectivity (up to 99% ee, >20:1 dr). This reaction does not require pre-prepared organometallic reagents and exhibits excellent substrate compatibility.

引用

页码：1448 / 1456

页数：9

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