Bridging the gap of vision restoration

被引:0
作者
Carleton, Maya [1 ]
Oesch, Nicholas W. [1 ,2 ,3 ]
机构
[1] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Neurosci Grad Program, La Jolla, CA 92093 USA
关键词
vision restoration; retinal degeneration; age related macular degeneration; retinitis pigmentosa; retinal prosthesis; retina; optogenetics; AGE-RELATED MACULOPATHY; COMPLEMENT FACTOR-H; RD10 MOUSE MODEL; MACULAR DEGENERATION; RETINITIS-PIGMENTOSA; OXIDATIVE STRESS; RETINAL DEGENERATION; CARDIOVASCULAR-DISEASE; GLOBAL PREVALENCE; VISUAL FUNCTION;
D O I
10.3389/fncel.2024.1502473
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Retinitis pigmentosa (RP) and Age-Related Macular Degeneration (AMD) are similar in that both result in photoreceptor degeneration leading to permanent progressive vision loss. This affords the possibility of implementing vision restoration techniques, where light signaling is restored to spared retinal circuitry to recreate vision. There are far more AMD patients (Wong et al., 2014), yet more resources have been put towards researching and developing vision restoration strategies for RP despite it rarity, because of the tractability of RP disease models. The hope is that these therapies will extend to the AMD population, however, many questions remain about how the implementation of prosthetic or optogenetic vision restoration technologies will translate between RP and AMD patients. In this review, we discuss the difference and similarities of RP and AMD with a focus on aspects expected to impact vision restoration strategies, and we identify key gaps in knowledge needed to further improve vision restoration technologies for a broad patient population.
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页数:14
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共 149 条
  • [71] Kolb H., SIMPLE ANATOMY RETIN
  • [72] The cell biology of the retinal pigment epithelium
    Lakkaraju, Aparna
    Umapathy, Ankita
    Tan, Li Xuan
    Daniele, Lauren
    Philp, Nancy J.
    Boesze-Battaglia, Kathleen
    Williams, David S.
    [J]. PROGRESS IN RETINAL AND EYE RESEARCH, 2020, 78
  • [73] Identification and characterization of rod-derived cone viability factor
    Léveillard, T
    Mohand-Saïd, S
    Lorentz, O
    Hicks, D
    Fintz, AC
    Clérin, E
    Simonutti, M
    Forster, V
    Cavusoglu, N
    Chalmel, F
    Dollé, P
    Poch, O
    Lambrou, G
    Sahel, JA
    [J]. NATURE GENETICS, 2004, 36 (07) : 755 - 759
  • [74] HISTOPATHOLOGY OF BONE SPICULE PIGMENTATION IN RETINITIS-PIGMENTOSA
    LI, ZY
    POSSIN, DE
    MILAM, AH
    [J]. OPHTHALMOLOGY, 1995, 102 (05) : 805 - 816
  • [75] Optogenetics for visual restoration: From proof of principle to translational challenges
    Lindner, Moritz
    Gilhooley, Michael J.
    Hughes, Steven
    Hankins, Mark W.
    [J]. PROGRESS IN RETINAL AND EYE RESEARCH, 2022, 91
  • [76] Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation
    Lores-Motta, Laura
    Paun, Constantin C.
    Corominas, Jordi
    Pauper, Marc
    Geerlings, Maartje J.
    Altay, Lebriz
    Schick, Tina
    Daha, Mohamed R.
    Fauser, Sascha
    Hoyng, Carel B.
    den Hollander, Anneke I.
    de Jong, Eiko K.
    [J]. OPHTHALMOLOGY, 2018, 125 (07) : 1064 - 1074
  • [77] The Argus® II Retinal Prosthesis System
    Luo, Yvonne Hsu-Lin
    da Cruz, Lyndon
    [J]. PROGRESS IN RETINAL AND EYE RESEARCH, 2016, 50 : 89 - 107
  • [78] Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    Maisonpierre, PC
    Suri, C
    Jones, PF
    Bartunkova, S
    Wiegand, S
    Radziejewski, C
    Compton, D
    McClain, J
    Aldrich, TH
    Papadopoulos, N
    Daly, TJ
    Davis, S
    Sato, TN
    Yancopoulos, GD
    [J]. SCIENCE, 1997, 277 (5322) : 55 - 60
  • [79] Cellular Origin of Spontaneous Ganglion Cell Spike Activity in Animal Models of Retinitis Pigmentosa
    Margolis, David J.
    Detwiler, Peter B.
    [J]. JOURNAL OF OPHTHALMOLOGY, 2011, 2011
  • [80] Optogenetic restoration of retinal ganglion cell activity in the living primate
    McGregor, Juliette E.
    Godat, Tyler
    Dhakal, Kamal R.
    Parkins, Keith
    Strazzeri, Jennifer M.
    Bateman, Brittany A.
    Fischer, William S.
    Williams, David R.
    Merigan, William H.
    [J]. NATURE COMMUNICATIONS, 2020, 11 (01)