Bridging the gap of vision restoration

被引:0
作者
Carleton, Maya [1 ]
Oesch, Nicholas W. [1 ,2 ,3 ]
机构
[1] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Neurosci Grad Program, La Jolla, CA 92093 USA
关键词
vision restoration; retinal degeneration; age related macular degeneration; retinitis pigmentosa; retinal prosthesis; retina; optogenetics; AGE-RELATED MACULOPATHY; COMPLEMENT FACTOR-H; RD10 MOUSE MODEL; MACULAR DEGENERATION; RETINITIS-PIGMENTOSA; OXIDATIVE STRESS; RETINAL DEGENERATION; CARDIOVASCULAR-DISEASE; GLOBAL PREVALENCE; VISUAL FUNCTION;
D O I
10.3389/fncel.2024.1502473
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Retinitis pigmentosa (RP) and Age-Related Macular Degeneration (AMD) are similar in that both result in photoreceptor degeneration leading to permanent progressive vision loss. This affords the possibility of implementing vision restoration techniques, where light signaling is restored to spared retinal circuitry to recreate vision. There are far more AMD patients (Wong et al., 2014), yet more resources have been put towards researching and developing vision restoration strategies for RP despite it rarity, because of the tractability of RP disease models. The hope is that these therapies will extend to the AMD population, however, many questions remain about how the implementation of prosthetic or optogenetic vision restoration technologies will translate between RP and AMD patients. In this review, we discuss the difference and similarities of RP and AMD with a focus on aspects expected to impact vision restoration strategies, and we identify key gaps in knowledge needed to further improve vision restoration technologies for a broad patient population.
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页数:14
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共 149 条
  • [1] PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23
    Ahmed, ZM
    Riazuddin, S
    Ahmad, J
    Bernstein, SL
    Guo, Y
    Sabar, MF
    Sieving, P
    Riazuddin, S
    Griffith, AJ
    Friedman, TB
    Belyantseva, IA
    Wilcox, ER
    [J]. HUMAN MOLECULAR GENETICS, 2003, 12 (24) : 3215 - 3223
  • [2] Gene Therapy in Inherited Retinal Diseases: An Update on Current State of the Art
    Amato, Alessia
    Arrigo, Alessandro
    Aragona, Emanuela
    Manitto, Maria Pia
    Saladino, Andrea
    Bandello, Francesco
    Battaglia Parodi, Maurizio
    [J]. FRONTIERS IN MEDICINE, 2021, 8
  • [3] An animal model of age-related macular degeneration in senescent Ccl-2-or Ccr-2-deficient mice
    Ambati, J
    Anand, A
    Fernandez, S
    Sakurai, E
    Lynn, BC
    Kuziel, WA
    Rollins, BJ
    Ambati, BK
    [J]. NATURE MEDICINE, 2003, 9 (11) : 1390 - 1397
  • [4] Anand R, 2000, OPHTHALMOLOGY, V107, P2224
  • [5] An update on retinal prostheses
    Ayton, Lauren N.
    Barnes, Nick
    Dagnelie, Gislin
    Fujikado, Takashi
    Goetz, Georges
    Hornig, Ralf
    Jones, Bryan W.
    Muqit, Mahiul M. K.
    Rathbun, Daniel L.
    Stingl, Katarina
    Weiland, James D.
    Petoe, Matthew A.
    [J]. CLINICAL NEUROPHYSIOLOGY, 2020, 131 (06) : 1383 - 1398
  • [6] Do Calcium Channel Blockers Rescue Dying Photoreceptors in the Pde6brd1 Mouse?
    Barabas, Peter
    Peck, Carolee Cutler
    Krizaj, David
    [J]. RETINAL DEGENERATIVE DISEASES: LABORATORY AND THERAPEUTIC INVESTIGATIONS, 2010, 664 : 491 - 499
  • [7] Etiology, pathogenesis, and experimental treatment of retinitis pigmentosa
    Baumgartner, WA
    [J]. MEDICAL HYPOTHESES, 2000, 54 (05) : 814 - 824
  • [8] The role of oxidative stress in the pathogenesis of age-related macular degeneration
    Beatty, S
    Koh, HH
    Henson, D
    Boulton, M
    [J]. SURVEY OF OPHTHALMOLOGY, 2000, 45 (02) : 115 - 134
  • [9] Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
    Block, ML
    Hong, JS
    [J]. PROGRESS IN NEUROBIOLOGY, 2005, 76 (02) : 77 - 98
  • [10] Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis
    Bourne, Rupert R. A.
    Flaxman, Seth R.
    Braithwaite, Tasanee
    Cicinelli, Maria V.
    Das, Aditi
    Jonas, Jost B.
    Keeffe, Jill
    Kempen, John H.
    Leasher, Janet
    Limburg, Hans
    Naidoo, Kovin
    Pesudovs, Konrad
    Resnikoff, Serge
    Silvester, Alex
    Stevens, Gretchen A.
    Tahhan, Nina
    Wong, Tien Y.
    Taylor, Hugh R.
    [J]. LANCET GLOBAL HEALTH, 2017, 5 (09): : E888 - E897