Successful treatment of low-risk myelodysplastic syndrome-related anemia in patients with chronic kidney disease with daprodustat: A report of two cases

被引：0

作者：

Kunimoto, Hiroyoshi ^{[1
]}

Sakuma, Takayuki ^{[1
]}

Ohashi, Takuma ^{[1
]}

Shirafuta, Mayoko ^{[1
]}

Teranaka, Hiroshi ^{[1
]}

Nakajima, Hideaki ^{[1
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Stem Cell & Immune Regulat, 3-9 Fukuura,Kanazawa Ku, Yokohama 2360004, Japan

来源：

EJHAEM | 2024年 / 5卷 / 06期

关键词：

anemia; case report; daprodustat; MDS; LENALIDOMIDE; SAFETY;

D O I：

10.1002/jha2.1057

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anemia is a major clinical manifestation seen in myelodysplastic syndromes (MDS). Treatment options for anemia in low-risk MDS are limited. Especially, oral medication which is uniformly effective for anemia in low-risk MDS is required. Hypoxia-inducible factor (HIF) prolyl hydroxylase (HIF-PH) inhibitors, such as daprodustat, are oral tablets effective for renal anemia. Pharmacological restoration of HIF activity by HIF-PH inhibitors may be beneficial for MDS-related anemia as well. Yet, their efficacy and safety against low-risk MDS are unclear. Here, we report two cases of low-risk MDS complicated with chronic kidney disease whose anemia responded to daprodustat treatment.

引用

页码：1335 / 1339

页数：5

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