Relationship of the Degree of Sarcopenia with the Severity of Nonalcoholic Fatty Liver Disease and Cardiometabolic Risk in Adolescents

被引：1

作者：

Kwon, Yoowon ^{[1
]}

Chung, Jin A. ^{[2
]}

Choi, You Jin ^{[3
]}

Lee, Yoo Min ^{[4
]}

Choi, So Yoon ^{[5
]}

Yoo, In Hyuk ^{[6
]}

Kim, Tae Hyeong ^{[7
]}

Jeong, Su Jin ^{[2
]}

机构：

[1] Chungnam Natl Univ, Sch Med, Sejong Hosp, Dept Pediat, Sejong 30099, South Korea

[2] CHA Univ, Sch Med, CHA Bundang Med Ctr, Dept Pediat, Seongnam 13496, South Korea

[3] Inje Univ, Ilsan Paik Hosp, Dept Pediat, Coll Med, Ilsan 10380, South Korea

[4] Soonchunhyang Univ, Coll Med, Dept Pediat, Bucheon Hosp, Bucheon 14584, South Korea

[5] Kosin Univ, Coll Med, Dept Pediat, Gospel Hosp, Busan 49267, South Korea

[6] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Pediat, Seoul 06591, South Korea

[7] Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Dept Pediat, Coll Med, Seoul 05278, South Korea

来源：

LIFE-BASEL | 2024年 / 14卷 / 11期

关键词：

nonalcoholic fatty liver disease; skeletal muscle mass; sarcopenia; triglyceride and glucose index; atherogenic index of plasma; INSULIN-RESISTANCE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; MUSCLE MASS; OBESITY; PREVALENCE; CHILDREN; HEALTH; INFLAMMATION; DIAGNOSIS;

D O I：

10.3390/life14111457

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The association between nonalcoholic fatty liver disease (NAFLD) and sarcopenia has been suggested. We investigated sarcopenia's impact on NAFLD severity and its relationship with cardiometabolic risk in adolescents. We conducted a retrospective study on 122 patients aged 13-18 years and diagnosed with both NAFLD and sarcopenia by laboratory tests, abdominal ultrasound (US), and multifrequency bioelectrical impedance analysis. Sarcopenia was stratified into tertiles based on the skeletal muscle-to-fat ratio (MFR), NAFLD severity was established by the US, and cardiometabolic risk was assessed by the triglyceride-glucose (TyG) index and the atherogenic index of plasma (AIP). Compared with the other patients, those in the lower MFR tertiles exhibited a greater severity of NAFLD (p < 0.001) and significantly higher TyG index and AIP. The independent effect of MFR was observed to have a negative correlation with the severity of NAFLD (p < 0.001). Based on the aforementioned results, the degree of sarcopenia can be considered as one of the risk factors of severe NAFLD and might be an indicator of cardiometabolic risk in adolescents. Weight training to reach the amount of muscle mass could be included in the treatment strategies to improve or prevent NAFLD in adolescents with sarcopenia.

引用

页数：10

共 54 条

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