Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise

被引：2
作者：
Cui, Xinxin [1 ,2 ]
Spanos, Michail [3 ,4 ,5 ]
Zhao, Cuimei [6 ]
Wan, Wensi [2 ]
Cui, Caiyue [2 ]
Wang, Lijun [1 ,2 ]
Xiao, Junjie [1 ,2 ]
机构：
[1] Shanghai Univ, Peoples Hosp Nantong 6, Affiliated Nantong Hosp, Cardiac Regenerat & Ageing Lab,Inst Geriatr,Sch Me, Nantong 226011, Peoples R China
[2] Shanghai Univ, Inst Cardiovasc Sci, Shanghai Engn Res Ctr Organ Repair,Minist Educ, Sch Life Sci,Joint Int Res Lab Biomat & Biotechnol, Shanghai, Peoples R China
[3] Massachusetts Gen Hosp, Cardiovasc Div, Boston, MA 02114 USA
[4] Harvard Med Sch, Boston, MA 02114 USA
[5] Albert Einstein Coll Med, NCB, Dept Internal Med, Bronx, NY USA
[6] Tongji Univ, Shanghai Tongji Hosp, Sch Med, Dept Cardiol, Shanghai 200065, Peoples R China
来源：
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2025年
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
Heart failure with preserved ejection fraction; Mitochondria; Exercise; Mitochondrial dynamics; Oxidative stress; PRESERVED EJECTION FRACTION; HEART-FAILURE; OXIDATIVE STRESS; RAT-HEART; MOUSE MODEL; CARDIOMYOPATHY; INFLAMMATION; ACTIVATION; MECHANISMS; NAD(+)/NADH;
D O I：
10.1007/s12265-025-10591-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
HFpEF is a prevalent and complex type of heart failure. The concurrent presence of conditions such as obesity, hypertension, hyperglycemia, and hyperlipidemia significantly increase the risk of developing HFpEF. Mitochondria, often referred to as the powerhouses of the cell, are crucial in maintaining cellular functions, including ATP production, intracellular Ca2+ regulation, reactive oxygen species generation and clearance, and the regulation of apoptosis. Exercise plays a vital role in preserving mitochondrial homeostasis, thereby protecting the cardiovascular system from acute stress, and is a fundamental component in maintaining cardiovascular health. In this study, we review the mitochondrial dysfunction underlying the development and progression of HFpEF. Given the pivotal role of exercise in modulating cardiovascular diseases, we particularly focus on exercise as a potential therapeutic strategy for improving mitochondrial function.Graphical abstractNote: This picture was created with BioRender.com
引用
收藏
页码：442 / 456
页数：15
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