Transdermal Delivery of Azilsartan: Formulation Strategies and Performance Evaluation

被引：0

作者：

Kasimedu, Saravanakumar ^{[1
]}

Devi, A. Rekha ^{[1
]}

Gangaiahgari, Ravi Kumar ^{[1
]}

Vijay, Rajyalakshmi Anem ^{[2
]}

Matam, Thanusree ^{[1
]}

Pommala, Nagaveni ^{[3
]}

Mudduluru, Niranjan Babu ^{[1
]}

机构：

[1] Seven Hills Coll Pharm Autonomous, Dept Pharmaceut, Tirupati 517561, Andhra Pradesh, India

[2] Sri Venkateswara Coll Pharm Autonomous, Dept Pharmaceut, Chittoor, Andhra Pradesh, India

[3] SV Univ, SVU Coll Pharmaceut Sci, Dept Pharmaceut, Tirupati, Andhra Pradesh, India

来源：

ASIAN JOURNAL OF PHARMACEUTICS | 2024年 / 18卷 / 04期

关键词：

Folding endurance; Hydrophobic polymers; Permeable membrane; Permeation rate; Swelling effect;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aims: Matrix-type systems were developed in the present study by using various polymers including sodium carboxymethyl cellulose and eudragits with various concentrations. Materials and Methods: In the present work, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising of Azilsartan with different concentrations of sodium carboxyl methyl cellulose and Eudragit using solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. Results and Discussion: The results obtained showed no physical-chemical incompatibility between the drug and the polymers. The in vitro drug diffusion studies from the formulation were found to be a sustained release effect. All the evaluation parameters obtained from the best formulation were found to be satisfactory. Conclusion: The data obtained from the in vitro release studies were fitted to various kinetic models; it was found that drug release follows the Peppas model release by diffusion technique from the polymer.

引用

页码：1296 / 1300

页数：5