A core microbiome signature as an indicator of health

被引：19

作者：

Wu, Guojun ^{[3
,4
,5
]}

Xu, Ting ^{[1
,2
]}

Zhao, Naisi ^{[8
]}

Lam, Yan Y. ^{[9
]}

Ding, Xiaoying ^{[7
]}

Wei, Dongqin ^{[6
]}

Fan, Jian ^{[6
]}

Shi, Yajuan ^{[6
]}

Li, Xiaofeng ^{[6
]}

Li, Mi ^{[6
]}

Ji, Shenjie ^{[6
]}

Wang, Xuejiao ^{[7
]}

Fu, Huaqing ^{[1
,2
]}

Zhang, Feng ^{[10
]}

Shi, Yu ^{[6
]}

Zhang, Chenhong ^{[1
,2
]}

Peng, Yongde ^{[7
]}

Zhao, Liping ^{[1
,2
,3
,4
,5
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Minist Educ, Key Lab Syst Biomed, Shanghai 200240, Peoples R China

[3] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Sch Environm & Biol Sci, Dept Biochem & Microbiol, New Brunswick, NJ 08854 USA

[4] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Ctr Microbiome Nutr & Hlth, New Brunswick, NJ 08901 USA

[5] Rutgers Jiaotong Joint Lab Microbiome & Human Hlth, New Brunswick, NJ 08854 USA

[6] Qidong Peoples Hosp, Dept Endocrinol & Metab, Qidong 226200, Jiangsu, Peoples R China

[7] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Endocrinol & Metab, Sch Med, Shanghai 200080, Peoples R China

[8] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA

[9] Univ Hong Kong, LKS Fac Med, Sch Clin Med, Dept Med, Hong Kong, Peoples R China

[10] Jiangnan Univ Wuxi, Affiliated Hosp, Clin Assessment Ctr Funct Food, Affiliated Hosp, Wuxi 214122, Jiangsu, Peoples R China

来源：

CELL | 2024年 / 187卷 / 23期

基金：

中国国家自然科学基金;

关键词：

GUT MICROBIOTA; DIETARY FIBER; MULTI-OMICS; DIAGNOSIS; BACTERIA; BENEFITS; QUALITY;

D O I：

10.1016/j.cell.2024.09.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gut microbiota is crucial for human health, functioning as a complex adaptive system akin to a vital organ. To identify core health-relevant gut microbes, we followed the systems biology tenet that stable relationships signify core components. By analyzing metagenomic datasets from a high-fiber dietary intervention in type 2 diabetes and 26 case-control studies across 15 diseases, we identified a set of stably correlated genome pairs within co-abundance networks perturbed by dietary interventions and diseases. These genomes formed a "two competing guilds"(TCGs) model, with one guild specialized in fiber fermentation and butyrate production and the other characterized by virulence and antibiotic resistance. Our random forest models successfully distinguished cases from controls across multiple diseases and predicted immunotherapy outcomes through the use of these genomes. Our guild-based approach, which is genome specific, database independent, and interaction focused, identifies a core microbiome signature that serves as a holistic health indicator and a potential common target for health enhancement.

引用

页码：6550 / 6565.e11

页数：28

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