Macrophage Activation Syndrome

被引:1
作者
Nigrovic, Peter A. [1 ,2 ]
机构
[1] Boston Childrens Hosp, Boston, MA 02115 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA
关键词
JUVENILE IDIOPATHIC ARTHRITIS; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; T-CELLS; INTERFERON-GAMMA; SOLUBLE INTERLEUKIN-2-RECEPTOR; HLH; ETOPOSIDE; CHILDREN; CYTOTOXICITY; DYSFUNCTION;
D O I
10.1002/art.43052
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Macrophage activation syndrome (MAS) is a state of immune hyperactivation that can result in life-threatening multisystem end-organ dysfunction. Often termed a "cytokine storm," MAS occurs among the rheumatic diseases most typically in Still's disease but also in systemic lupus erythematosus and Kawasaki disease. MAS can also accompany infection, malignancy, and inborn errors of immunity. This review provides a practical, evidence-based guide to the understanding, recognition, and management of MAS in children and adults, with a primary focus on MAS complicating Still's disease.
引用
收藏
页码:367 / 379
页数:13
相关论文
共 86 条
  • [1] Application of the 2016 EULAR/ACR/PRINTO Classification Criteria for Macrophage Activation Syndrome in Patients with Adult-onset Still Disease
    Ahn, Sung Soo
    Yoo, Byung-Woo
    Jung, Seung Min
    Lee, Sang-Won
    Park, Yong-Beom
    Song, Jason Jungsik
    [J]. JOURNAL OF RHEUMATOLOGY, 2017, 44 (07) : 996 - 1003
  • [2] NK cell detachment from target cells is regulated by successful cytotoxicity and influences cytokine production
    Anft, Moritz
    Netter, Petra
    Urlaub, Doris
    Prager, Isabel
    Schaffner, Samantha
    Watzl, Carsten
    [J]. CELLULAR & MOLECULAR IMMUNOLOGY, 2020, 17 (04) : 347 - 355
  • [3] Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project
    Baldo, Francesco
    Erkens, Remco G. A.
    Mizuta, Mao
    Rogani, Greta
    Lucioni, Federica
    Bracaglia, Claudia
    Foell, Dirk
    Gattorno, Marco
    Jelusic, Marija
    Anton, Jordi
    Brogan, Paul
    Canna, Scott
    Chandrakasan, Shanmuganathan
    Cron, Randy Q.
    De Benedetti, Fabrizio
    Grom, Alexei
    Heshin-Bekenstein, Merav
    Horne, AnnaCarin
    Khubchandani, Raju
    Ozen, Seza
    Quartier, Pierre
    Ravelli, Angelo
    Shimizu, Masaki
    Schulert, Grant
    Scott, Christiaan
    Sinha, Rashmi
    Ruperto, Nicolino
    Swart, Joost F.
    Vastert, Sebastiaan
    Minoia, Francesca
    [J]. RHEUMATOLOGY, 2024, : 32 - 44
  • [4] DIFFERENCES IN CEREBROSPINAL-FLUID PENETRATION OF CORTICOSTEROIDS - POSSIBLE RELATIONSHIP TO THE PREVENTION OF MENINGEAL LEUKEMIA
    BALIS, FM
    LESTER, CM
    CHROUSOS, GP
    HEIDEMAN, RL
    POPLACK, DG
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (02) : 202 - 207
  • [5] Behrens EM, 2007, J RHEUMATOL, V34, P1133
  • [6] Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice
    Behrens, Edward M.
    Canna, Scott W.
    Slade, Katharine
    Rao, Sheila
    Kreiger, Portia A.
    Paessler, Michele
    Kambayashi, Taku
    Koretzky, Gary A.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) : 2264 - 2277
  • [7] Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study
    Bergsten, Elisabet
    Horne, AnnaCarin
    Arico, Maurizio
    Astigarraga, Itziar
    Egeler, R. Maarten
    Filipovich, Alexandra H.
    Ishii, Eiichi
    Janka, Gritta
    Ladisch, Stephan
    Lehmberg, Kai
    McClain, Kenneth L.
    Minkov, Milen
    Montgomery, Scott
    Nanduri, Vasanta
    Rosso, Diego
    Henter, Jan-Inge
    [J]. BLOOD, 2017, 130 (25) : 2728 - 2738
  • [8] The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor α-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis
    Bleesing, Jack
    Prada, Anne
    Siegel, David M.
    Villanueva, Joyce
    Olson, Judyann
    Ilowite, Norman T.
    Brunner, Hermine I.
    Griffin, Thomas
    Graham, Thomas B.
    Sherry, David D.
    Passo, Murray H.
    Ramanan, Athimalaipet V.
    Filipovich, Alexandra
    Grom, Alexei A.
    [J]. ARTHRITIS AND RHEUMATISM, 2007, 56 (03): : 965 - 971
  • [9] The syndrome of hemophagocytic lymphohistiocytosis in primary immunodeficiencies: implications for differential diagnosis and pathogenesis
    Bode, Sebastian F. N.
    Ammann, Sandra
    Al-Herz, Waleed
    Bataneant, Mihaela
    Dvorak, Christopher C.
    Gehring, Stephan
    Gennery, Andrew
    Gilmour, Kimberly C.
    Gonzalez-Granado, Luis I.
    Gross-Wieltsch, Ute
    Ifversen, Marianne
    Lingman-Framme, Jenny
    Matthes-Martin, Susanne
    Mesters, Rolf
    Meyts, Isabelle
    van Montfrans, Joris M.
    Schmid, Jana Pachlopnik
    Pai, Sung-Yun
    Soler-Palacin, Pere
    Schuermann, Uta
    Schuster, Volker
    Seidel, Markus G.
    Speckmann, Carsten
    Stepensky, Polina
    Sykora, Karl-Walter
    Tesi, Bianca
    Vraetz, Thomas
    Waruiru, Catherine
    Bryceson, Yenan T.
    Moshous, Despina
    Lehmberg, Kai
    Jordan, Michael B.
    Ehl, Stephan
    [J]. HAEMATOLOGICA, 2015, 100 (07) : 978 - 988
  • [10] Features, Treatment, and Outcomes of Macrophage Activation Syndrome in Childhood-Onset Systemic Lupus Erythematosus
    Borgia, R. Ezequiel
    Gerstein, Maya
    Levy, Deborah M.
    Silverman, Earl D.
    Hiraki, Linda T.
    [J]. ARTHRITIS & RHEUMATOLOGY, 2018, 70 (04) : 616 - 624